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Shh signaling involved in Pitchfork regulated primary cilia disassembly during mouse palate development

Other Titles
 Pitchfork 유전자가 mouse 구강구개측 발육에서 Shh signaling과 primary cilia 분해에 대한 조절 
Issue Date
Dept. of Dental Science/박사
Pitchfork, a mouse embryonic node gene, is associated with ciliary targeting complexes located at the basal body during primary cilia disassembly. Various developmental disorders, such as cleft palate, and disorders of the lung, kidney and heart, have been known as an association with ciliary defects. Mammalian palate development is regulated by complex processes. Many cellular and molecular events, such as cell proliferation, apoptosis, cell migration and the epithelial mesenchymal transition, regulate proper palate development, and surely, some abnormalities in palate development lead to cleft palate. To determine the function of Pitchfork during palate development, we examined Pitchfork expression patterns and morphological changes in the developing secondary palate after Pitchfork over-expression. During periods E12.5 and E13.5 in mice, Pitchfork was highly expressed in the developing mouse secondary palate. Morphological differences were observed in vitro in cultured palates in the Pitchfork over-expression group compared to the control group. Pitchfork over-expression induced primary cilia disassembly during palate development. Shh and Ptch1 expression levels and palatine rugae morphology were altered in the over-expressed Pitchfork group during palate development. Therefore, the proper expression levels of Pitchfork may play a pivotal role in normal secondary palate morphogenesis.
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2. College of Dentistry (치과대학) > Others (기타) > 3. Dissertation
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