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Association of age-related changes in circulating intermediary lipid metabolites, inflammatory and oxidative stress markers, and arterial stiffness in middle-aged men

Other Titles
 중년층 남성에게서 노화와 중간 지질 대사체, 염증반응,산화 스트레스 지표와 동맥경화도의 변화와의 연관성 
Authors
 라보연 
Issue Date
2012
Description
Dept. of Science for Aging/석사
Abstract
The relationships between age-related changes in circulating endogenous metabolites, inflammatory and oxidative stress markers, and arterial stiffness in 57 middle-aged (34–55 years), nonobese men were studied over the course of 3 years. Arterial stiffness was measured using brachial-ankle pulse wave velocities (ba-PWV). Plasma metabolomic profiling was performed using ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS). After 3 years, decreased HDL-cholesterol and increased malondialdehyde (MDA) and ox-LDL levels were observed. Among 15 identified lipids, lysoPCs (C16:0, C18:0, C18:2, C20:4, and C20:5) and linoleyl carnitine were the major plasma metabolites that contributed to the age-related differences. LysoPC16:0 (variable importance in the projection [VIP] value: 6.2029) was the most important plasma metabolite for evaluating these changes. LysoPC16:0 levels were positively correlated with changes in MDA (r=0.413), high-sensitivity C-reactive protein(hs-CRP) (r=0.509), IL-6 (r=0.497), and ba-PWV (r=0.283) levels. ba-PWV levels were positively correlated with changes in inflammatory and oxidative stress markers. In a subgroup analysis of subjects with decreased ba-PWVs vs. increased ba-PWVs, changes in waist-to-hip ratios(WHR) and levels of lysoPC16:0, ba-PWV, IL-6, MDA, and P-selectin were significantly different. Our results suggest that age-related increases in lysoPC16:0 can contribute to lipid peroxidation, the activation of proinflammatory phenotypes, and arterial stiffness.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/134230
Appears in Collections:
2. Thesis / Dissertation (학위논문) > 1. College of Medicine (의과대학) > Master's Degree (석사)
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