The clinical effect of locally delivered minocycline associated with the flap surgery for treatment of chronic advanced periodontitis : a split mouth design

Abstract

The purpose of the present study was to determine the effectiveness of adjunctive application of locally delivered minocycline ointment associated with the flap surgery for the treatment of patients with chronic advanced periodontitis.A total of twenty patients with chronic advanced periodontitis were treated in a split mouth design study to either adjunctive application of locally delivered minocycline ointment associated with flap surgery (test) or only flap surgery (control), and additional application was performed at 3 months post operation. Clinical evaluation of plaque index (PI), probing depth (PD), bleeding on probing (BOP), gingival recession (GR) and clinical attachment level (CAL) were conducted at baseline, 3 months and 6 months after treatment.Clinical evaluation revealed that both groups had clinical improvement, however there was statistically significant reduction in PD, BOP, and significant gain of CAL in the test group than the control group after 6 months post–operation (p<0.05).Adjunctive application of locally delivered minocycline may be beneficial in the surgical treatment protocol of chronic advanced periodontitis.