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Evaluation of regional cerebral glucose metabolism in patients with corticobasal degeneration using F-18 fluorodeoxyglucose positron emission tomography

Other Titles
 F-18 플루디옥시글루코즈 양전자방출단층촬영기를 이용한 피질기저핵변성 환자 군에서의 국소적 뇌 포도당 대사의 평가 
Issue Date
Dept. of Medicine/석사
Backgrounds and Objectives: The corticobasal degeneration (CBD) is a neurodegenerative disease showing the progressive asymmetric extrapyramidal motor deficits, apraxia and cortical sensory loss. The asymmetric fronto-parietal cortical and subcortical hypometabolism was demonstrated in the previous F-18 deoxyglucose positron emission tomography (FDG PET) scan studies. We investigated the hypometabolic pattern of Korean CBD patients using quantitative FDG PET and voxel based comparison method. Methods: Twelve patients with CBD and 16 age-matched controls were included in this study. Quantitative brain FDG PET and magnetic resonance imaging (MRI) scan studies were performed simultaneously in all subjects. For better spatial normalization of PET image, individual MR image was used for the normalization template. Using the group comparison model in the Statistical Parametric Mapping 2 (SPM) software, we compared the local glucose metabolism between the CBD patients and normal controls. Results: The global glucose metabolic activity of the CBD patients was significantly lower than that of controls. In SPM analysis, the CBD patients showed significantly decreased glucose metabolism in the fronto-parieto-temporal cortices, thalamus and caudate nucleus. The contralateral hemisphere to the more affected side showed decreased glucose metabolism in much wider fronto-parieto-temporal cortices. Conclusions: Quantitative FDG PET analysis showed asymmetric fronto-parieto-temporal hypometabolism in patients with CBD and is useful method in diagnosing the CBD.
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1. College of Medicine (의과대학) > Others (기타) > 2. Thesis
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