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A multicenter phase I/II trial of capecitabine, oxaliplatin and gemcitabine (XELOXGEM) in patients with advanced colorectal carcinoma pretreated with irinotecan
DC Field | Value | Language |
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dc.contributor.author | 김세현 | - |
dc.date.accessioned | 2015-12-24T08:39:56Z | - |
dc.date.available | 2015-12-24T08:39:56Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/133939 | - |
dc.description | Dept. of Medicine/석사 | - |
dc.description.abstract | Background: Capecitabine plus oxaliplatin (XELOX) is an effective second-line regimen for advanced colorectal carcinoma (CRC) patients pretreated with irinotecan. Previous studies have shown supra-additive anti-tumor activity of gemcitabine (GEM) when administered with oxaliplatin. We investigated the dose, toxicity, and efficacy of a second-line XELOXGEM regimen in CRC patients pretreated with irinotecan.Patients and methods: Patients with metastatic or recurrent CRC who failed after a first-line irinotecan-containing regimen received escalating doses of gemcitabine (600, 800, 1000 mg/m2 d1, d8) followed by capecitabine (1000 mg/m2 b.i.d d1-14) and oxaliplatin (100 mg/m2 d1) on a 21-day cycle.Results: A total of 38 patients were treated. At 800 mg/m2, two of six patients experienced dose-limiting toxicities (diarrhea and thrombocytopenia). Therefore, the clinically recommended dose was defined as 600 mg/m2 gemcitabine (d1, d8) followed by 1000 mg/m2 capecitabine (b.i.d d1-14) and 100 mg/m2 oxaliplatin (d1). The most common grade 3/4 toxicities were neutropenia (32%), thrombocytopenia (13%), anemia (11%) and peripheral neuropathy (11%). Ten (26.3%) and 23 (60.5%) patients experienced partial remission and stable disease, respectively. The median progression-free survival and overall survival were 5.4 months (95% CI 3.8-6.9 months) and 17.7 months (95% CI 8.4-26.9 months), respectively.Conclusions: The XELOXGEM triplet combination is an active and safe second-line regimen for advanced CRC patients pretreated with irinotecan. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | A multicenter phase I/II trial of capecitabine, oxaliplatin and gemcitabine (XELOXGEM) in patients with advanced colorectal carcinoma pretreated with irinotecan | - |
dc.title.alternative | Irinotecan 투약 이후 진행한 대장암 환자들을 대상으로 Capecitabine, Oxaliplatin, Gemcitabine 병합요법(XELOXGEM)의 효과와 독성을 확인하는 1,2상 임상연구 | - |
dc.type | Thesis | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.localId | A00607 | - |
dc.contributor.alternativeName | Kim, Se Hyun | - |
dc.contributor.affiliatedAuthor | 김세현 | - |
dc.type.local | Thesis | - |
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