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Muscle weakness after repeated injection of botulinum toxin type a evaluated according to bite force measurement of human masseter muscle

Other Titles
 보툴리눔 A형 독소의 반복주사 이후 저작력 측정을 통해 평가한 사람 교근의 약화양상 
Issue Date
2011
Description
Dept. of Dental Science/박사
Abstract
Botulinum toxin type A (BTX-A) has been applied successfully to treat masseteric hypertrophy, but it can cause muscle weakness. To measure the change in maximum bite force (MBF) after BTX-A injection into the human masseter muscle and to evaluate the influence of a booster (repeated) injection, thirty volunteers completed 18-week follow-up, and MBF was measured. At 18 weeks after the first injection, a booster injection was given to 14 patients, and they were followed up until 18 weeks from the booster injection.Mean MBF was approximately 20% lower at 2 weeks than before the injection, and it recovered gradually after 4 weeks to return to the preinjection level at 12 weeks. MBF differed significantly between before the injection and at 2, 4, and 8 weeks after the injection (p<0.05).In the booster injection group (n = 14), MBF was markedly lower at 6 weeks (p<0.05), and it recovered gradually in 12 weeks. In conclusion, MBF was significantly lower after booster injection of BTX-A into the human masseter muscle, but it gradually recovered in a predictable pattern, and the degree of discomfort experienced by the subjects had little effect on normal mastication.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/133924
Appears in Collections:
2. 학위논문 > 2. College of Dentistry (치과대학) > 박사
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