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Allele frequencies of human leukocyte antigen-G in Korean population

Other Titles
 한국인의 HLA-G 대립유전자 빈도 
Authors
 박윤희 
Department
 Dept. of Laboratory Medicine (진단검사의학교실) 
Issue Date
2012
Description
Dept. of Medicine/박사
Abstract
The human leukocyte antigen (HLA)-G is a nonclassical major histocompatibility complex class I molecule with relatively limited polymorphism. The differences in allele frequency according to ethnicity and country have not been studied enough, so far. Therefore, fundamental data including allele frequencies and polymorphism are needed for studies on immunological function of HLA-G in each population. We investigated allele frequencies and 14-bp polymorphism of the HLA-G in Koreans. HLA-G alleles and 14-bp polymorphisms were determined by sequence-based typing analysis of exons 2–4 and polymerase chain reaction of the 3''-UTR region in 200 unrelated individuals. Genotyping analysis identified eight different HLA-G alleles, which indicates that the Korean population presents limited HLA-G allelic polymorphism. HLA-G*01:01:01:01 and G*01:04:01 were frequent alleles (42.5% and 34.0%), and allelic frequencies were similar to those of other Asian populations. The 14-bp deletion alleles are higher (78%) in Koreans, although the frequencies of the 14-bp insertion/deletion polymorphism have been known to be nearly equal in many Caucasian populations. HLA-G*01:01:08 was reported strong linkage disequilibrium with the 14-bp deletion in a previous report; the same allele was accompanied with 14-bp insertion in our study. There are a few studies investigating allele frequencies, and most of them were studied before high resolution method era. This is the first study regarding HLA-G genotypes in Korean, which were identified by high-resolution method. From this study, we identified HLA-G frequencies of a Korean population and expect this study could help further investigations for immunological and clinical implications of HLA-G.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 3. Dissertation
Yonsei Authors
Park, Youn Hee(박윤희) ORCID logo https://orcid.org/0000-0001-8458-1495
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/133763
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