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Influence of the resorbability of the osteoconductive bone substitutes on the healing of extraction sockets in beagle dogs

Other Titles
 골 대체제의 흡수가 성견 발치와 치유에 미치는 영향 
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Dept. of Dental Science/박사
[영문]The aim of the study was to evaluate the influence of resorption in graft materials on the healing of extraction sockets in beagle dogs.Third premolars in all four quadrants of 8 beagle dogs were extracted. 8 extraction sites per an animal resulting from the biradicular teeth were randomly treated with either one of hydroxyapatite (HA), biphasic calcium phosphate (BCP), β-tricalcium phosphate (β-TCP) or control (no graft) group. Animals were sacrificed at 2, 4 and 8 weeks. Histologic sections in mesio-distal plane were evaluated and the proportions (%) of new bone, remaining graft materials and soft tissue comprised of provisional matrix or bone marrow were histomorphometrically analyzed. New bone formation was significantly higher in control group (74.48%) followed by β-TCP (51.12%), BCP (41.42%) and HA (31.12%) at healing periods. Resorption of the graft materials was significantly higher in β-TCP followed by BCP and HA group. β-TCP showed active resorption of the particle and replacement with newly formed bone. HA rarely resorbed and stably incorporated with new bone in spite of multinucleated cells on the surface. BCP appeared to have superficial resorption of the graft material with new bone replacement at β-TCP content, when HA content showed rare resorption with stable incorporation into new bone. Within the limit of this study, it was concluded that the proportion of newly formed bone was largest in the control group with higher proportion in bone marrow at 8 weeks. Resorption of the material and replacement with new bone was significantly higher in β-TCP than other grafted groups at healing intervals. HA stably incorporated into new bone with rare resorption. BCP simultaneously showed stable incorporation of the particle to maintain space and resorption with bone substitution.
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2. College of Dentistry (치과대학) > Others (기타) > 3. Dissertation
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