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성견 3면 골내낭에서 Paste형 Calcium Sulfate가 치주조직 치유에 미치는 영향

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 (The) effects on paste type calcium sulfate on the periodontal healing of 3-wall intrabony defects in dogs 
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[한글] 치주질환에 의해 상실된 치주조직의 재생을 위해 골이식재의 사용등의 많은 치료법들이 사용되고 있다. 다양한 골이식재의 종류가 소개되고 있으나 그 중 합성골의 경우, 경제적으로 많은 양을 얻어낼 수 있다는 점에서 연구가 활발히 진행되고 있는데, 이 중 Calcium Sulfate제재는 칼슘염을 충분히 함유한 관계로 오래 전부터 임상영역에서 사용되어왔는데, 치과영역에서는 이식재로서 사용되어 왔으며 김 등의 여러 연구에서 증진된 신생골과 신부착을 보고하여 왔다. 하지만 경화열의 발생 및 너무 빠른 흡수속도 등의 문제를 제기하여 이에 새로이 제작된 Calcium Sulfate제재의 이식효과를 알아보는 연구가 필요하게 되었다. 본 연구는 성견에서 외과적으로 형성된 깊이 4mm, 근원심 4mm, 폭경 4mm의 3면 골내낭에 치주박리 소파수술만 한 군을 대조군으로 하고 특수 제작된 Paste형 Calcium Sulfate를 이식한 군을 실험군으로 하여 시술한 후 8주 후에 희생하여 치유 결과를 조직학적으로 관찰한 결과 다음과 같은 결과를 얻었다. 1. 접합상피의 길이는 대조군, 실험군에서 각각 0.52 0.26mm, 0.56 0.25mm로 나타났으며 유의성있는 차이는 없었다. 2. 결합조직유착의 길이는 대조군, 실험군에서 각각 1.74 1.06mm, 1.28 0.57mm로 나타났으며 유의성있는 차이는 없었다. 3. 신생골형성의 길이는 대조군, 실험군에서 각각 2.01 0.95mm, 2.62 0.81mm로 나타났으며 유의성있는 차이는 없었다. 4. 신생백악질의 길이는 대조군, 실험군에서 각각 1.86 0.80mm, 2.77 0.86mm로 나타났으며 실험군에서 백악질 형성에 유의성있는 차이가 있었다(P<0.01). 이상의 결과로 볼 때 3면 골내낭에서 Paste형 Calcium Sulfate는 백악질 형성을 증진시키는 데 도움이 되므로, 재료 자체의 생체 적합성을 개선하면 치주조직 재생에 도움을 주는 재료라 사료된다.
[영문] There are numerous kind of materials and techniques to regenerate the periodontal tissue which has been lost due to destructive periodontal disease, including bone graft material. Many bone graft materials have been reported and among these materials, synthetic material has been developed fin the long time because of its sufficient supply economically. Calcium sulfate which was evaluated as including much calcium, has been used in the clinical field. In the dental field calcium sulfate has been used as bone graft material and Kim reported that improved bone formation and more amount of new attachment after grafting calcium sulfate. but, because calcium sulfate has the problem that it generates the heat in setting period and resolves fast, we need to evaluate the effect of the improved calcium sulfate on periodontal tissue. The present study evaluates the effect of paste type calcium sulfate on the epithelial migration, alveolar bone regeneration, cementum formation and gingival connective tissue attachment in intrabony defect in dogs. Four millimeter deep and four millimeter wide 3-wall defects were surgically created in the mesial or distal aspects of premolars or molars. the test group received paste-type calcium sulfate with a flap procedure and the control group underwent flap procedure only. Histologic analysis after 8 weeks of healing revealed the following results : 1. The length of epithelial growth(the distance from CEJ to the apical end of JE) was 0.52 0.26mm in the control and 0.56 0.25mm in the test group. there was no statistically significant difference between the two groups. 2. The length of connective tissue adhesion was 1.74 1.06mm in the control and 1.28 0.57mm in the test group. there was no statistically significant difference between the two groups. 3. The length of new bone was 2.01 0.95mm in the control and 2.62 0.81mm in the test group. there was no statistically significant difference between the two groups. 4. The length of new cementum was 1.86 0.80mm in the control and 2.77 0.86mm in the test group. there was a statistically significant difference between the two groups.(P<0.01) These results suggest that the use of paste type calcium sulfate in 3-wall intrabony defects has significant effect on new cementum formation , but doesn''t have any significant effect on the prevention of junctional epithelium migration and new bone formation. Finally, the paste type calcium sulfate that is used in this study is suggested to be the material that can have a significant effect on the periodontal healing, if its biocompatibility is improved.
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2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 2. Thesis
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