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家兎의 肝臟 및 腎臟에서의 色素分泌 過程에 關하여

Other Titles
 Studies on the dye-secretory processes of the liver and the kidney in the rabbit. 
Authors
 남숙현 
Issue Date
1965
Description
의학과/석사
Abstract
[한글]

[영문]

That different mechanisms are involved in the secretory processes by the liver and the kidney of variousddyssh has been indicated by Sperber (1959), Kim and Hong (1962). Andrews (1958) suggested that a striking difference in the dye-secretory mechanism existed even in the same organ from species to species. Hence, the attempt has been made to study in the rabbit the secretory processes by the liver and the kidney of either phenol red (PSP), bromsulfalein (BSP) or indocyanine green in the presence of Na-acetate, Na-taurocholate, P-Aminohippurate (PAH) or Benemid.

In 37 rabbits, weighing about 2 kg., anesthetized with either, a dye was administered in such a manner that the plasma concentration was kept at a relatively constant level throughout the whole experimental period. Hepatic bile and urine samples were quantitatively collected through the canulae which were previously inserted into the common bile duct(with the cystic duct ligated) and the urinary bladder, respectively, while arterial samples were taken from a femoral artery. After 50 min from the onset of dye administration, these samples were obtained every 10 min for a period of 40 min. This was followed by the

administration of either Na-acetate, Na-taurocholate, PAH or Benemid with a repetition of the same sample collecting procedures just stated.

The results may be summarized as follows:

1) Na-acetate augmented urinary clearance of PSP by nearly 200 per cent, but lowered urinary BSP clearance by about 50 per cent. It enhanced biliary BSP clearance by 40% and had no effect on biliary PSP clearance.

2) Na-taurocholate lowered biliary and urinary clearance of PSP by 10 per cent and 30 per cent, respectively, and had no effect on both biliary and urinary cleqarance of BSP.

3) PAH lowered both biliary and urinary excretion of BSP and PSP< while it lowered the biliary excretion of indocyanine green which was excreted only inthe bile.

4) Benemid suppressed BSP excretion by the liver and the kidney.

5) Paper chromatographic analysis of PSP and of BSP in the bile and urine samples gave the following results:

a) PSP was excreted in the urine and bile only in free forms, and no modification in the excretory pattern was brought about by Na-taurocholate.

b) BSP was excreted in the urine in 4 different conjugated forms and in the bile in both 3 different conjugated forms and in a free form. Na-taurocholate modified the excretory pattern of the urinary BSP<
Full Text
https://ymlib.yonsei.ac.kr/catalog/search/book-detail/?cid=CAT000000045183
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 2. Thesis
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/127024
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