胃冷凍이 肝機能에 미치는 影響

Abstract

[한글]

[영문]

Since Wangensteen et al.(1958) introduced gastric hypothermia for the control of massive upper gastrointestinal hemorrhage, ample evidence has accumulted that gastric hypothermia markedly alters gastric function. Recent findings indicate that the physiologic changes induced by this form of cooling are not limited to the stomach. Data from many centers have shown that gastric cooling affects hepatic blood flow, circulatory blood volume, pancreatic and renal functions.

In contrast to studies of the heart and brain, tests of hepatic function during hypothermia have been few. In this situation it would certainly seem proper that the effects of gastric freezing itself upon the normal liver be first evaluated.

The purpose of this study was to ascertain the effects of gastric freezing on liver function in the normal anesthetized dogs.

Fifteen mongrel dogs of both sees, weighting form 12 to 22 kg., were starved for 12 hours before gastric freezing, and they were then subjected to gastric freezing under general anesthesia with pentothal sodium(20mg./kg.). Gastric freezing was maintained for 50 minutes, and serial blood samples for liver function test were

taken before the freezing, and 12 hors, 24 hours, 48 hours, 72 hours and 96 hours after the freezing, respectively.

The results are as follows:

1. SGOT activity in ten dogs was 37±10.0 units before gastric freezing. After the freezing it showed rapid rise with a peak of 128±62.9 units at 12 hours, and gradually returned to normal in 72 hours.

2. SGPT activity in thirteen dogs was 35±5.7 units before the freezing. After the freezing it showed rapid rise with a peak of 79±30.3 units at 12 hours and slowly returned to normal in 72 hors.

3. Serum total protein level in fifteen dogs was 6.6±0.51gm.% before the freezing. After the freezing it showed progressively decreasing values, and lowest levels of 5.2±0.99 and 5.2±0.65 gm.% at 48 and 72 hours respectively, and thereafter it showed a tendency toward gradual increase.

4. A/G ratio showed no significant change before and after gastric freezing.

5. Serum alkaline phosphatase activity showed no significant change before and after gastric freezing.