초생아황달의 광선조사(光線照射)치료 효과에 관한 연구

Abstract

[한글]

STUDY ON THE EFFECT OF PHOTOTHERAPY ON NEONATAL JAUNDICE

Sun Hee Lee

Department of Medical Science, The Graduate School, Yonsei University

In 1958, Cremer had demonstrated that serum bilirubin concentration of new born

infant can be reduced by exposure to light. There were many reports about the

effect of phototherapy on hyperbilirubinemia and premature baby.

A controlled clinical trial has been carried out among 48 full term infant who

were selected by random sampling to test the effectiveness of artificial 300 foot

candle white fluorescent light in normal physiologic jaundice. Twenty four (Male

11, Female 13) control group and 24 (Male 11, Female 13) phototherapy group were

divided alternately. Infant in phototherapy group were exposed to light (Apart with

the light source about 100cm above the infant) starting in the first 24 hours of

life, usually in the first 8 hours and continued for 3 days except feeding time and

parent visiting time which may be mounted to 5 or 6 hours a day. The infant were

unclothed except for a eye cover and diaper. Infant in the control group were

managed in the same manner, except exposure to light. All infants with pathologic

conditions were excluded. Blood samples were collected in Natelson microblood

collecting tubes by heel puncture daily using the tip of a No. 11 blade.

Approximately 0.1ml to 0.2ml of serum was obtained and bilirubin level determined

by the method of Hsia and Associates.

The following results were obtained.

The bilirubin levels of the cord blood shows no significant difference between

two groups and its average is 0.8 mg/dl. The serum bilirubin levels of the

phototherapy group is 4.050±0.362 mg/dl on Day 1, 6.591±0.366 mg/dl on Day 2,

7.0±0.844 mg/dl on Day 3. The serum bilirubin levels of the control group is

5.720±0.442 on Day 1, 7.608±0.421 mg/dl on Day 2, 9,164±0.836 mg/dl on Day 3.

(Listed on Table 3). The mean serum bilirubin values of the phototherapy group were

lower than those of the control group 0.870 mg/dl on Day 1, 1.007 mg/dl on Day 2,

2.164 mg/dl on Day 3.

1) The rise in Bilimbin over the base level in phototherapy group was

4.033±0.424 mg/dl on Day 1, 5.595±0.378 mg/dl on Day 2, and 7.123±0.842 mg/dl on

Day 3. (Listen on table 5).

2) The rise in bilimbin over the base level of the phototherapy group were

significantly lower than control group on Day 1 (P value<0.025), on Day 2 (P

value<0.1), and on Day 3 (P value<0.025).

[영문]

In 1958, Cremer had demonstrated that serum bilirubin concentration of new born infant can be reduced by exposure to light. There were many reports about the effect of phototherapy on hyperbilirubinemia and premature baby.

A controlled clinical trial has been carried out among 48 full term infant who were selected by random sampling to test the effectiveness of artificial 300 foot candle white fluorescent light in normal physiologic jaundice. Twenty four (Male 11, Female 13) control group and 24 (Male 11, Female 13) phototherapy group were divided alternately. Infant in phototherapy group were exposed to light (Apart with the light source about 100cm above the infant) starting in the first 24 hours of life, usually in the first 8 hours and continued for 3 days except feeding time and parent visiting time which may be mounted to 5 or 6 hours a day. The infant were unclothed except for a eye cover and diaper. Infant in the control group were managed in the same manner, except exposure to light. All infants with pathologic conditions were excluded. Blood samples were collected in Natelson microblood collecting tubes by heel puncture daily using the tip of a No. 11 blade.

Approximately 0.1ml to 0.2ml of serum was obtained and bilirubin level determined by the method of Hsia and Associates.

The following results were obtained.

The bilirubin levels of the cord blood shows no significant difference between two groups and its average is 0.8 mg/dl. The serum bilirubin levels of the phototherapy group is 4.050±0.362 mg/dl on Day 1, 6.591±0.366 mg/dl on Day 2, 7.0±0.844 mg/dl on Day 3. The serum bilirubin levels of the control group is

5.720±0.442 on Day 1, 7.608±0.421 mg/dl on Day 2, 9,164±0.836 mg/dl on Day 3. (Listed on Table 3). The mean serum bilirubin values of the phototherapy group were lower than those of the control group 0.870 mg/dl on Day 1, 1.007 mg/dl on Day 2,

2.164 mg/dl on Day 3.

1) The rise in Bilimbin over the base level in phototherapy group was 4.033±0.424 mg/dl on Day 1, 5.595±0.378 mg/dl on Day 2, and 7.123±0.842 mg/dl on Day 3. (Listen on table 5).

2) The rise in bilimbin over the base level of the phototherapy group were significantly lower than control group on Day 1 (P value<0.025), on Day 2 (P value<0.1), and on Day 3 (P value<0.025).