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Dinitrochlorobenzene(DNCB)에 의한 우췌(wart)의 치료효과

Other Titles
 Therapeutic effect of dinitrochlorobenzene(DNCB) on warts 
Issue Date
1980
Description
의학과/석사
Abstract
[한글] 우췌(wart)는 human papovavirue에 의한 감염성 피부질환으로 각종의 치료방법이 있으나 현재까지 만족할만한 것은 없다. 1973년 Greenberg등이 처음으로 1-chloro-2,4-dinitro-benzene(DNCB)을 우췌에 도포하여 좋은 효과가 있음을 관찰하고 이는 새포매개면역반응과 관계가 있다고 보고한 이래 Lewis(1973), 李(1975), 金등(1975), 李와李(1976), Young(1976), Buckner와 Price(1976)도 유사한 결과를 보고한 바 있다. 그러나 이들은 DNCB를 우췌에 직접 도포한 것으로서 이의 작용기전이 세포매개면역과 관계가 있다면 병변과 관계없이 DNCB를 정상피부에 도포하여도 치유될 수 있을 것으로 사료된다. 이에 저자는 편평우췌(verruca plana) 44명, 심상성체(verruca vulgaris) 14명 총 58명의 우췌환자를 대상으로 하여 0.4% DNCB용액 0.5㎖로 정상피부에 감작시킨 후 일주 2회 0.1% DNCB연고로 정상피부에 challenge시켜 관찰하여 다음과 같은 결과를 얻었다. 1. DNCB에 의한 감작은 58예중 45예(77.6%)에서 1회 도포로 감작되었고 나머지 13예중12예(20.7%)는 0.25㎖의 DNCB용액으로 재차 도포하여 감작되었으며 1예는 3차 도포로 감작되어 58예 전예에서 감작되었다. 2. DNCB에 의한 치료효과를 보면 편평우췌 44예중 37예(84.1%), 심상성우췌 14예중 8예(37.1%)가 치유되어 편평우췌에서 더 좋은 치유효과를 볼 수 있었으며 치유된 환자중 편평우췌 6예, 심상성우췌 1예에서는 DNCB감작만으로 치료되었다. 3. DNCB challenge로 치유된 환자의 치유기간을 보면 편평우췌 31예중 28예(90.3%) 심상성우췌 7예 전예에서 challenge 10주내에 완치되었다. 4. DNCB 도포부위에 접촉성피부염의 증상이 나타나나 치료를 중단할 정도는 아니였고심한 경우에는 부신피질홀몬제 도포로 치유되었으며 치유후 경한 색소 침착외에는 특기할만한 부작용은 없었다.
[영문] Warts are benign infective tumors induced by a papovavirus. Many therapeutic modalities are available for the treatment of warts but there is no satisfactory method because warts often come back and may at times prove completely incurable . In 1973 Greenberg et al first reported that 1-chloro-2,4-dinitrobenzene (DNCB) which induced the cell-mediated immunity was affective in the resolution of warts. Thereafter the same results were reported by Lewis (1973) ,Lee (1975), Kim et at (1975), Young (1976), Lee & Lee (1976) and Buckner & Price (1978). If DNCB brings about rejection of warts by enhancement of cell-mediated immunity, we postulate that wart should be curable by application of DNCB to the unaffected normal skin of the patient with wart. In this study the resolution of warts were evaluated by application of DNCB to the unaffected normal skin of 58 patients with warts (verruca plana 44, verruca vulgaris 14). The patients were sensitized by application of 0.5 ml of 0.4% DNCB solution to the normal skin of right shoulder and 2 weeks later were challenged by application of 0.1% DNCB ointment to the normal skin of left shoulder twice per week. results were summerized as follows; Of 58 patients 45 (77.6%) became sensitized to 0.5 ml of DNCB solution, 12 of 13 unsensitized patients (20.7%) became sensitized after another application of 0.25 ml of DNCB solution and the last one unsensitized patient after reapplication of 0.25 ml of DNCB solution, thus all of the patients became sensitized to DNCB solution. of 44 patients 37 (84.1%) with verruca plana and 8 of 14 patients (57.1%) with verruca vulgaris had total resolution, so the therapeutic effect on verruca plana was better than that on verruca vulgaris. There were 7 patients in which verrucae completely resolved following DNCB sensitization only, requiring no further treatment, including verruca plana 6 and verruca vulgaris l. Within 10 weeks of challenge, 28 of 31 patients (90.3%) with verruca plana and all of 7 patients (100%) with verruca vulgaria cured by challenge had total resolution of warts. There were no specific side-reactions due to this treatment except mild allergic contact dermatitis on DNCB applied area and slight hyperpigmentation after healing.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/126830
Appears in Collections:
2. 학위논문 > 1. College of Medicine > 석사
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