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Influences of triggering receptor expressed on myeloid cells-1 genetic polymorphisms on genotypes and phenotypes in Korean patients with inflammatory bowel diseases
DC Field | Value | Language |
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dc.contributor.author | 정은석 | - |
dc.date.accessioned | 2015-11-21T07:55:00Z | - |
dc.date.available | 2015-11-21T07:55:00Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/125420 | - |
dc.description | Dept. of Medicine/석사 | - |
dc.description.abstract | [한글] [영문]Triggering receptor expressed on myeloid cells-1 (TREM-1) has been shown to play a crucial role in the propagation of inflammatory responses. Recent studies have reported that TREM-1 expression is up-regulated in patients with inflammatory bowel disease (IBD). We hypothesized that TREM-1 genetic polymorphisms might be associated with IBD development and its phenotypes. We genotyped three TREM-1 single nucleotide polymorphisms (SNPs, rs2234237, rs3789205, and rs9471535) and evaluated the relationships between these SNPs and IBD genotypes and phenotypes. We found that TREM-1 SNPs are significantly associated with the development of intestinal Behcet’s disease, and in particular with skin involvement and risk of azathioprine use. However, TREM-1 SNPs were not significantly associated with the development of Crohn’s disease or ulcerative colitis. The results of our study suggest that TREM-1 SNPs may play a significant role in the development of intestinal Behcet’s disease and may have modest effects on disease severity. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Influences of triggering receptor expressed on myeloid cells-1 genetic polymorphisms on genotypes and phenotypes in Korean patients with inflammatory bowel diseases | - |
dc.title.alternative | 한국인 염증성 장질환 환자에서 triggering receptor expressed on myeloid cells-1의 유전자 다형성이 질환 감수성과 표현형에 미치는 영향 분석 | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Jung, Eun Suk | - |
dc.type.local | Thesis | - |
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