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T869C polymorphism in the transforming growth factor-β1 gene may be associated with the predisposition to idiopathic pulmonary fibrosis in Korean
DC Field | Value | Language |
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dc.contributor.author | 손지영 | - |
dc.date.accessioned | 2015-11-21T07:52:34Z | - |
dc.date.available | 2015-11-21T07:52:34Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/125328 | - |
dc.description | Dept. of Medicine/석사 | - |
dc.description.abstract | [한글] [영문]Background: Transforming growth factor-β1 (TGF-β1) is a key cytokine that plays a critical role in the development of idiopathic pulmonary fibrosis (IPF). The genotypes of T869C polymorphism are associated with the predisposition to fibrotic lung disease. Methods: We investigated a single nucleotide polymorphism at exon 1 nucleotide position 29 (T→C) of the TGF-β1 gene. Eighty-five age- and sex-matched healthy controls and 85 subjects with surgically confirmed IPF were investigated, using polymerase chain reaction and restriction enzyme fragment length polymorphism techniques.Results: The IPF patients consisted of 55 men and 30 women. The mean age was 61 ± 8 years. With regard to smoking status, fifty-one (60%) of the 85 IPF patients were smokers, and 34 non-smokers. The distribution of genotypes in IPF patients was TT 37 cases (43.5%), and TC or CC 48 cases (56.5%). It was significantly different from that of the controls (TT 27.1%, and TC or CC 72.9%, p=0.039). The presence of TT genotype was significantly associated with a reduction in PaO2 and a increase in D(A-a)O2 upon initial diagnosis (t-test, p=0.006 and 0.009, respectively), but TT genotype was not associated with disease progression or survival. Conditional logistic regression including smoking status and genotype of TGF-β1 T869C polymorphism suggested that the TT genotype carried a 2 fold higher risk of IPF development, as compared with the TC or CC genotype (95% CI 1.053~3.799, p=0.034).Conclusions: This study suggests that TGF-β1 gene T869C polymorphism may be associated with a predisposition to IPF in Korea. Larger studies are required to confirm genetic association for TGF-β1 gene polymorphism and IPF. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | T869C polymorphism in the transforming growth factor-β1 gene may be associated with the predisposition to idiopathic pulmonary fibrosis in Korean | - |
dc.title.alternative | TGF- β1(Transforming growth factor-β1) 유전자의 T869C 다형성과 한국인 특발성 폐섬유증 발생 소인과의 관련성 | - |
dc.type | Thesis | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.localId | A01996 | - |
dc.identifier.url | https://ymlib.yonsei.ac.kr/catalog/search/book-detail/?cid=CAT000000078985 | - |
dc.contributor.alternativeName | Son, Ji Young | - |
dc.contributor.affiliatedAuthor | 손지영 | - |
dc.type.local | Thesis | - |
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