The histologic evaluation of the biodegradability and tissue response of the absordable collagen sponge (ACS) following implantation on the 3 wall intrabony defects

Abstract

[한글]

[영문]Objective: Absorbable collagen sponge(ACS) has been extensively used as carriers in bone tissue engineering due to its biocompatibility, biodegradability, and low antigenicity. For evaluation of its biocompatibility, this study is compared the 8-weeks histologic results of periodontal healing with open flap curettage implanted buffer/Absorbable collagen sponge or open flap debridement only in the intrabony defects.Methods: Bilateral 3-wall intrabony periodontal defects were surgically induced in the premolar region in the maxilla and mandible in 8 young adult Korean mongrel dogs. The surgical control groups received a flap operation only, while the collagen groups were treated with phosphate-buffered saline/Absorbable collagen sponge. The subjects were sacrificed 8weeks after the operation, and a comparative histologic evaluation was performed.Results: Clinical healing was uneventful without adverse effects. No meaningful differences in histologic analysis about regenerated tissues were observed between both groups. Absorbable Collagen Sponge was almost degraded in 8-week histologic specimens. No sites exhibited ankylosis and few sites appeared root resorption.Conclusions: Absorbable Collagen Sponge has been shown favorable, biocompatible tissue response and relatively rapid biodegradation. So, It may be used a suitable carriers for 3-wall intrabony defects treatment.