The effect of succinnylated atelocollagen and ablative fractional resurfacing laser on striae distensae

Abstract

[한글]

[영문]

Striae distensae are a dermal atrophic scar with epidermal thinning and decreased collagen and elastic fiber. There is no “gold standard” treatment modality in the treatment of striae distensae. Collagen is a major extracellular matrix component and is important in wound healing. Ablative CO2 fractional laser is effective in various cutaneous scars. This study was attempted to evaluate the effect of succinnylated atelocollagen and ablative CO2 fractional laser in the treatment of striae distensae. Patients were divided into two groups and received 3 laser treatments at 4-week interval. Clinical improvement was evaluated by patients and two masked physicians by observing the comparative photographs using a 4-point scale. Skin biopsies were performed in randomly selected 6 patients before treatment and 4 weeks after the final treatment. Ablative fractional resurfacing laser was effective in clinical improvement of striae distensae. Statistically significant differences were partly observed between collagen treated group and placebo treated group. Clinical improvement scored by doctors showed more improvement in collagen group. However scoring by patients did not show significant differences in collagen and placebo treated group. In conclusion ablative fractional resurfacing laser is effective in the treatment of striae distensae and succinylated atelocollagen might improve the striae distensae, but the further research with large group of patients is needed.