2. 제 1,제2군의 조직수분함유량은 대조군의 정상조직수분함유량인 64.5%보다 모두 높았다.
3. 제 1, 제 2군의 술후 24시간의 조직수분함유량은 각기 71.9 %, 66.7 %로서 제 1, 제 2군의 술후 48시간의 조직수분함유량인 70.0%, 66.6%보다 다소 높았다.
4. 현미경학적 소견에서 제 2군은 제 1군에 비해 염증세포의 침윤과, 부종이 감소한 상을 볼 수 있었다.
[영문]
The purpose of this study is to observe the effect of Indomethacin on postsurgical edema in rats.
For this Study,35 male rats, each weighing about 300 grams, were divided into 2 groups.
Group 1: Composed of 10 rats that received no medication.
Group 2: Composed of 20 rats that were administered Indomethacin intramuscularly (5mg/kg), preoperatively and 12 hours postoperatively.
Results were obtained as follows.
1. Tissue water content of Group 2, that was administered Indomethacin intramuscularly were markedly reduced compared to that of Group 1 that received no medication.
2. Tissue water content of Group 1 and 2 were all higher than control group which received no surgery.
3. Tissue water content of Group 1 and 2 after 24 hours, were slightly higher than tissue water content after 48 hours.
4. In the microscopic findings, the infiltration of inflammatory cells and edema were markedly reduced in Group 2 than that of Group 1.