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치과이식을 위한 dense calcium phosphate ceramics 제재의 물리적 성질 및 생물학적 안전성에 관한 연구

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 (The) mechanical, physical and biological safety study of dense calcium phosphate ceramics for the application of dental implant 
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인체내의 골조직과 치아의 성분에 가장 가깝고 골조직과 연조직간의 친화력이 우수한 생물학적인 치과이식 재료로써 최근에 많은 관심을 갖고 응용되는 Calcium phosphate를 Isostatic press를 이용한 소결법으로 1000℃, 1100℃, 1200℃의 온도에서 각각 소결한 후

Vitallium 침봉을 접착시킨 원주형의 시편을 제작하여 기공율, 부피비중, 상대비중, X-선 회절분석, 압축강도, 전단강도, 미세강도, 전자현미경 소견등의 기계적, 물리적 성질과 HeLa 세포를 이용한 조직배양법으로 생물학적안전성을 관찰하여서 다음과 같은 결론을 얻었다.

1. 1200℃에서 소결한 tricalcium phosphate ceramics는 다른 온도에서보다 높은 기계적 강도를 나타내었다.

2. 소결온도가 상승함에 따라 전체적인 기공율은 감소하나 반대로 기공의 크기는 크게 나타났다.

3. 1200℃에서 소결한 tricalcium Phosphate ceramics의 상대밀도는 96.65%로써 다른 온도에서보다 높게 나타났다.

4. Tricalcium phosphate를 1000℃∼1200℃ 범위에서 소결한 경우 모두 β-whitlockite로 상변태 하였다.

5. Triealcium phosphate ceramics는 소결온도에 상관없이 모두 vitallium과함께 생물학적인 안전성을 보였다.


The calcium phosphate ceramics are bioactive materials for dental implant that resembles those of dental enamel, dentin and bone, which forming tight bond resembles ankylosis with surrounding bone and soft tissue.

Dense calcium phosphate ceramics were made of commercially available tricalcium phosphate salts by compression and subsequent sintering at each temperature 1000℃, 1100℃ and 1200℃.

Subsequently artificial teeth were made of cylindrical form that consist of a vitallium rod for post & core and a surface of sintered dense calcium phosphate ceramics for interfacing with alveolar bone.

In this experimental study, mechanical and physical properties of sintered calcium phosphate ceramics were obtained from measurement of bulk density, relative density, apparent porosity, compressive strength, modulus of rupture strength, vickers hardness, average pore and grain size. The biological safety of these materials was tested from the tissue culture method using HeLa Cells.

The results of this study were obtained as follows;

1. Tricalcium phosphate ceramics sintered at temperature 1200℃ exhibited better mechanical strengths.

2. As much as sintering temperature arised, apparent porosity was reduced, but avarage pore size was larged.

3. The relative density of tricalcium phosphate ceramics sintered at 1200℃ was 96.65%.

4. When tricalcium phosphate salts sintered at temperature between 1000℃ and 1200℃, they were transformed to β-whitlockite.

5. Tricalcium phosphate ceramics exhibited biological safety regardless of sintering temperature.
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2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 3. Dissertation
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