성견 치주질환 이환 발치와에 즉시임프란트 매식술시 Titanium plasma sprayed 임프란트와 Hydroxyapatite coated 임프란트의 계면조직에 관한 연구

Abstract

[한글]

치아발거후 치조골 소실에 따른 구강내의 심미적, 기능적 문제를 해소하기 위해 임프란트매식술이 널리 사용되기 시작하였다. 이때 골유착은 매식술성공의 필수적인 조건으로. 이를 달성하기 위한 매식재료, 방법, 계면조직에 관한 연구가 진행되어 왔다. 현재 널리

사용되고있는 재료로 titanium과 hydroxyapatite가 소개되어 있으며, 치조골이 완전히 치유된 후에 매식할 경우 나타나는 치조골 흡수기간을 최소화하기 위해 즉시매식술이 이용되기 시작하였다.

본 연구의 목적은 원주형의 Hydroxyapatite(HA) 임프란트와 Titanium plasma sprayed(TPS) 임프란트를 성견 치주질환 이환발치와에 즉시매식한 경우 두 재료간의 골 유착율을

조직형태학적 분석을 통해 비교해보고자 한다.

이를 위해 성견의 제 3, 4 소구치에 교정용 탄성사를 결찰하여 만성치주염을 유발하고 12주간 방치한 후 해당치아를 조심스럽게 발거하고 TPS 임프란트를 즉시매식한 경우를 대조군으로, HA-coated 임프란트를 즉시매식한 경우를 실험군으로 설정하여 술 후 12주의

골유착율을 조직학적으로 비교관찰하고 조직형태학적 분석을 하여 다음과 같은 결과를 얻었다.

1. 대조군과 실험군 모두 염증세포의 침윤없이 양호한 치유상태를 보였다.

2. 전체적인 골유착율은 대조군에서 48.5%, 실험군에서 68.8%로 나타났으나, 대조군과 실험군사이의 통계학적인 유의 차는 존재하지 않았다(p<0.05).

3. hole부위 골유착율은 대조군에서 40.6%, 실험군에서 70.27로 통계학적인 유의 차를 보였다(P<0.05).

4. 하부 골유착율은 대조군에서 52.1%, 실험군에서 73.3%로 통계학적인 유의 차를 보였다(P<0.05).

5. 실험군에서 HA와 골조직은 경계를 구별할 수 없는 치밀한 결합양상을 보였다.

HISTOLOGICAL COMPARISONS OF TITANIUM PLASMA SPRAYED IMPLANT AND HYDROXYAPATITE

COATED IMPLANT TO BONE INTERFACE IN PERIODONTALLY INVOLVED EXTRACTION SOCKETS IN

DOGS

Jin-Sook Kim, D.D.S,

Department of Dental Science, Graduate School, Yonsei University

(Directed by Prof. Chong Kwan Kim, D.D.S., M.S.D., Ph D.)

Dental implants have been widely used in the treatment of esthetic and functional

problems of the mouth due to alveolar bone loss, after tooth extraction. The

success of implantation strongly depends on osseointegration. For ogseointegration,

implant material, methodology, and design have been investigated.

For materials, two popular materials at present are titanium and hydroxyapatite.

For methods, immediate implantation is being used recently.

The purpose of this study is to evaluate osseointegration between the unthreaded

cylindrical TPS implant and the HA-coated implant by a histomorphometric analysis.

For this analysis, experimental periodontits was induced on the 3, 4 premolars of

adult dogs by the ligation of orthodontic threads. Thereafter, each tooth was

extracted. TPS. implants and HA-coated implants were immediately inserted in the

extraction socket.

In control group, TPS implants were immediately inserted, and In experimental

group, HA implants were immediately inserted.

The dogs were sacrificed after 12 weeks, then the specimens were prepared for LM

and histomorphometric analysis.

The conclusion of this study is as follows

1. In both control and experimental group, no inflammatory cells were observed.

2. The results of the histomorphometric analysis showed that the total

osseointegration was 48.5% in control group, and 68.8% in experimental group.

The experimental group was higher than the control group, and the difference was

not statistically significant(p<0.05).

3. The results of the histomorphometric analysis skewed that the

osseointegrationin the hole was 40.6% in control group, and 70.2% in experimental

group.

The experimental group was higher than the control group, and the difference was

statistically significant (p<0.05).

4. The results of the histomorphometric analysis showed that the osseointegration

in the lower part was 52.1% in control group, and 73.3% in experimental group.

The experimental group was higher than the control group, and the difference was

statistically significant (p<0.05).

5. In experimental group, the bone to HA interface seemed to be mixed of bone and

HA. We could not distinguish HA from the bone. The HA coating was detached from the

titanium surface.

[영문]

Dental implants have been widely used in the treatment of esthetic and functional problems of the mouth due to alveolar bone loss, after tooth extraction. The success of implantation strongly depends on osseointegration. For ogseointegration,

implant material, methodology, and design have been investigated.

For materials, two popular materials at present are titanium and hydroxyapatite.

For methods, immediate implantation is being used recently.

The purpose of this study is to evaluate osseointegration between the unthreaded cylindrical TPS implant and the HA-coated implant by a histomorphometric analysis.

For this analysis, experimental periodontits was induced on the 3, 4 premolars of adult dogs by the ligation of orthodontic threads. Thereafter, each tooth was extracted. TPS. implants and HA-coated implants were immediately inserted in the extraction socket.

In control group, TPS implants were immediately inserted, and In experimental group, HA implants were immediately inserted.

The dogs were sacrificed after 12 weeks, then the specimens were prepared for LM and histomorphometric analysis.

The conclusion of this study is as follows

1. In both control and experimental group, no inflammatory cells were observed.

2. The results of the histomorphometric analysis showed that the total osseointegration was 48.5% in control group, and 68.8% in experimental group.

The experimental group was higher than the control group, and the difference was not statistically significant(p<0.05).

3. The results of the histomorphometric analysis skewed that the osseointegrationin the hole was 40.6% in control group, and 70.2% in experimental group.

The experimental group was higher than the control group, and the difference was statistically significant (p<0.05).

4. The results of the histomorphometric analysis showed that the osseointegration in the lower part was 52.1% in control group, and 73.3% in experimental group.

The experimental group was higher than the control group, and the difference was statistically significant (p<0.05).

5. In experimental group, the bone to HA interface seemed to be mixed of bone and HA. We could not distinguish HA from the bone. The HA coating was detached from the titanium surface.