3. 평균발병연령은 21.9세(남자 : 20.7세, 여자 : 22.9세)이며 내원평균연령은 27.8세(남자 : 26.7세, 여자 : 28.8세)였고, 펑균이환기간은 6.0년이었다. 25세 이전에 발병한 환자가 전채의 62.9%를 차지하였으며, 호발 연령군은 6-15세군(30.4%) 이었다
4. 초발병병은 76.8%가 단발병소로 나타났으며 71.1%가 노출부에 발생하였다. 초발 부위로는 얼굴(24.5%)이 가장 빈도가 높았으며 얼굴부위에서는 특히 이마 (19.2%)에 많이 나타났고 여자(24.4%)는 남자(12.1%)에 비해 목부위의 초발병변 발생이 많았다.
5. 내원시 환자의 73.6%가 병이 진행 중이였으며, 일부 환자에서 소양감(9.6%) 또는 작열감(0.8%)의 증상을 보였다.
6. 가장 흔한 유발인자는 외상(44.1%)이었고 다음으로는 정신적 긴장, 일광화상, 일광조사, 염증, 임신 및 출산과 피임제 순이었으며, 일광조사는 병변의 악화와 완화에 모두 관련이 있었다.
7. 가장 빈도가 높았던 내원 전 치료법은 국소 스테로이드제 도포법(46.8%)이었다.
8. 전체 환자의 27.0%에서 백모증이 나타났으며 가족럭은 12.2%, 계절에 따른 악화가 15.4%에서 그리고 Koebner's 현상이 18.0%에서 관찰되었다.
9. 병변의 평균침범범위는 7.3%(남자 : 7.6% 여자 : 7.0%)로 남녀 모두 5%이하 침범군(71.6%)이 가장 많았다.
10. 분절형은 비분절형에 비해 백모증의 발생빈도가 높고(81.7% : 21.0%) 통계학적으로 의의있게(p<0.05) 발병연령 및 내원연령이 낮고 이환기간이 짧은 임상적 특성을 보였으며 비분절형에서는 분절헝보다 면연학적 또는 알러지성 병인을 암시하는 질환들과 높은 연관성을 가져 두 군의 발병에는 서로 다른 병원론적 기전이 관련됨을 추측할 수 있었다.
Clinical study of vitiligo and comparative study of type A and type B vitiligo
Min Seok Song
Department of Medical Science The Graduate School, Yonsei University
(Directed by professor Yoon-Kee Park)
This is an analysis of 1315 vitiligo patients who had vested vitiligo special
clinic in Severance Hospital. In addition, comparative clinical study of
non-segmental type(type A) and segmental type(type B) vitiligo patients to
investigate the hypothesis concerning the pathogenesis Of vitiligo was done.
The results are summarized as follows:
1. There were 609 Hales(46.3%) and 706 females(53.7%).
2. There were 660 cases(50.2%) of generalized type, 654 cases(49.7%) of localized
type and one case of universal type vitiligo. Among them 203 cases(15,4%) were
non-segmental tyre and 1112 cases(84.6%) were segmental type.
3. The mean age of onest was 21.9 years (male: 20.7, female: 22.9) and the mean
age of visit was 27.8 years (male: 26.7, female: 28.8) .
4. Mede of onset was single in 75.8%.
5. The most common site of initial involvement was face(24.5%), especially the
forehead(19.2%), and the neck was more commonly involved in female(24.4%) than in
male(12.1%).
6. The disease was progressive in 73.6% of patients at the visit.
7. Pruritus(9.6%) and burning sense(0.8%) were observed in some patient.
8. The most common precipitating factor was trauma(44.1%) .
9. The most common previous treatment was topical steroid therapy(46.8%) .
10. The most common degree of depigmented lesion was 5-10%(71.6%) and the mean
percentage of depigmented lesion was 7.3%(male: 7,6%, female: 7.0%).
11. Poliosis was observed in 27.0% and family history was present in 12.2% of
patients.
12. Clinically type B vitiligo occured at younger age and had shorter duration of
disease progression and more poliosis than type A vitiligo. Association with
diseases with a proven or suggested allergic or immunological etiolicy was more
often found in type A, which findings support the hypothesis that type A and type B
vitiligo have a different pathogenesis.
[영문]
This is an analysis of 1315 vitiligo patients who had vested vitiligo special clinic in Severance Hospital. In addition, comparative clinical study of non-segmental type(type A) and segmental type(type B) vitiligo patients to investigate the hypothesis concerning the pathogenesis Of vitiligo was done.
The results are summarized as follows:
1. There were 609 Hales(46.3%) and 706 females(53.7%).
2. There were 660 cases(50.2%) of generalized type, 654 cases(49.7%) of localized type and one case of universal type vitiligo. Among them 203 cases(15,4%) were non-segmental tyre and 1112 cases(84.6%) were segmental type.
3. The mean age of onest was 21.9 years (male: 20.7, female: 22.9) and the mean age of visit was 27.8 years (male: 26.7, female: 28.8) .
4. Mede of onset was single in 75.8%.
5. The most common site of initial involvement was face(24.5%), especially the forehead(19.2%), and the neck was more commonly involved in female(24.4%) than in male(12.1%).
6. The disease was progressive in 73.6% of patients at the visit.
7. Pruritus(9.6%) and burning sense(0.8%) were observed in some patient.
8. The most common precipitating factor was trauma(44.1%) .
9. The most common previous treatment was topical steroid therapy(46.8%) .
10. The most common degree of depigmented lesion was 5-10%(71.6%) and the mean percentage of depigmented lesion was 7.3%(male: 7,6%, female: 7.0%).
11. Poliosis was observed in 27.0% and family history was present in 12.2% of patients.
12. Clinically type B vitiligo occured at younger age and had shorter duration of disease progression and more poliosis than type A vitiligo. Association with diseases with a proven or suggested allergic or immunological etiolicy was more often found in type A, which findings support the hypothesis that type A and type B vitiligo have a different pathogenesis.