(The) influences of sympathomimetic amines on melanophores of the frog skin
Authors
조정구
Issue Date
1970
Description
의학과/석사
Abstract
[한글]
THE INFLUENCES OF SYMPATHOMIMETIC AMINES ON MELANOPHORES OF THE FROG SKIN
Chung Koo Cho
Department of Medical Science, The Graduate school, Yonsei University
(Directed by Prof. Tae Ha Woo)
The chromatic activity and potency of various sympathomimetic amines were
examined in the normal frogs using the Hogben and Slome Index as a simple method
for measuring melanophore responses.
All the sympathomimetic amines tested in this experiment exhibited the marked
aggregation of melanophores. Among these amines, the order of potency in producing
the melanophore-aggregation was catecholethylamine derivatives (epinephrine and
isoproterenol) 〉 monohydroxyphenylethylamine derivative (tyramine) with exception
of phenylephrine 〉 nonhydroxyphenylethylamine derivatives (ephedrine and
propadrine). Of catecholethylamine derivatives, the melanophoreaggregating activity
of epinephrine was more potent than that of isoproterenol. One the other hand,
phenylephrine belong to the monodydroxyphenylethylamine derivatives was the least
potent agent that the other amines tested.
[영문]
The chromatic activity and potency of various sympathomimetic amines were examined in the normal frogs using the Hogben and Slome Index as a simple method for measuring melanophore responses.
All the sympathomimetic amines tested in this experiment exhibited the marked aggregation of melanophores. Among these amines, the order of potency in producing the melanophore-aggregation was catecholethylamine derivatives (epinephrine and
isoproterenol) 〉 monohydroxyphenylethylamine derivative (tyramine) with exception of phenylephrine 〉 nonhydroxyphenylethylamine derivatives (ephedrine and
propadrine). Of catecholethylamine derivatives, the melanophoreaggregating activity of epinephrine was more potent than that of isoproterenol. One the other hand,
phenylephrine belong to the monodydroxyphenylethylamine derivatives was the least potent agent that the other amines tested.