11. 매년 주증상의 평균 재발회수는 구강궤양 14.6회/년, 외으부궤양 7.2회/년, 피부증상 8.0회/년, 안증상 4.8회/년으로 구강궤양의 재발이 가장 빈번햇다.
12. 한 환자에서 가지고 있던 주증상의 조합은, 불완전형은 구강궤양, 외음부궤양, 피부증상의 조합(65.3%)이 가장 많았고, 용의형은 구강궤양, 피부증상의 조합(54.8%)이 가
장 많았다.
13. 가족중 재발하는 구강궤양이나 베체트 증후군을 갖고있는 빈도는 어머니(10.4%), 형제 및 자매(7.7%), 아버지(2.6%), 배우자(1.4%)순이었다.
이상의 결과로 보아 베체트증후군은 20대후반의 여자에서 많이 발생하며 거주지는 대도시가 많았다.최초발생 주증상은 구강궤양이 가장 많았고, 구강궤양의 재발이 가장 빈번했으며, 구강궤양의 평균 유병기간이 가장 길엇고 최초 주증상 발생후 제 2의 주증상 발생
은 5~6년 걸렸다. 외국의 보고서와의 차이는 우리연구에서 여자의 비율이 높은 점이다.
Epidemiologic findings of Behcet's Syndrome
Moo Yon Cho
Department of Medical Science, The Graduate School, Yonsei University
(Directed by ProfessorSungnack Lee, M.D.)
Behcet's syndrome was first described by Hulusi Behcet in 1937 with the clinical
presentation of frequently recurring oral and enital ulcers, and various skin and
eye lesions of unknown etiology. The etiology, pathogenesis, heredity and
prevalence of this disease are still unknown. For the purpose of epidemiologic
study, the patients who visited Severance Hospital Behcet's Syndrome Speciality
Clinic were grouped by Shimizu classification into the complete, incomplete and
suspected types and evaluated. The results of the evaluation with respect to
personal characteristics, geogrophic distribution, socioeconomic characteristics,
family history and clinical characteristics are as follows.
1. The incidence among the subgroups was incomplete type (46.3%), suspected type
(36.7%), complete type (17.0%) and the male to female ratio was 0.61:1.
2. The average age of onset was 29.1 years for males and 27.6 years for females.
3. The yearly incidence was less than 10 cases per year until 1970. When it began
to increase, reaching a maximum of 78 cases in 1983.
4. Regionally Seoul had the greatest number of patients, and there was no
significant difference first occurred and the present address.
5. The occupational distribution among males included office workers, 31.5%;
drivers, 10.6%; laborors, 7.9%; teachers, 7.4$; engineers, 6.5%, and among females
was office workers, 6.7%; labrors, 2.8%; unemployed, 81.7%.
6. Among the presumed aggrevation factors, oral ulcers and recurent tonsillitis
(20.8%) were the most frequent and aggrevation of the disease occurred more
frequently in the summer (8.4%).
7. Excerbation in realation to menstruation was premenstrual (12.8%), during
menstruation (5.3%) and postmenstrual (4.8%).
8. The initial symptoms were oral ulcers (80.6%), skin lesions(10.3%), genital
ulcer (6.3%) and eye symptoms (2.8%).
9. The average duration between the appearance of the first and second major
manifestations was 5.2 years for the complete type, 6.3 years for the incomplete
type and 6.3 years for the suspected type, 6.3 years for the incomplete type and
6.3 years for the suspected type.
10. The average duration of the symptoms at the time of diagnosis was 6.4 years
for oral ulcer, 3.2 years for genital ulcers, 3.1 years for skin lesions and 2.6
years for eye lesions, with the oral ulcers showing the longest duration of
symtoms.
11. The rate of symptom recurrence per years were for genital ulcers, 8.0
times/years for skin lesion and 4.8 times/years for eye lesions.
12. Combinations of major manifestations most commonly included oral ulcers,
genital ulcers and skin lesions (65.3%) for the incomplete type, and oral ulcers
and skin lesions (54.8%) for the suspected type.
13. The existence of recurrent oral ulcers of Behcet's syndrome in the families
of patients with Behcet;s syndrom was 10.0% for mothers, 7.7% for siblings, 5.2%
for fathers and 1.4% for partners.
[영문]
Behcet's syndrome was first described by Hulusi Behcet in 1937 with the clinical presentation of frequently recurring oral and enital ulcers, and various skin and eye lesions of unknown etiology. The etiology, pathogenesis, heredity and prevalence of this disease are still unknown. For the purpose of epidemiologic
study, the patients who visited Severance Hospital Behcet's Syndrome Speciality Clinic were grouped by Shimizu classification into the complete, incomplete and suspected types and evaluated. The results of the evaluation with respect to personal characteristics, geogrophic distribution, socioeconomic characteristics, family history and clinical characteristics are as follows.
1. The incidence among the subgroups was incomplete type (46.3%), suspected type (36.7%), complete type (17.0%) and the male to female ratio was 0.61:1.
2. The average age of onset was 29.1 years for males and 27.6 years for females.
3. The yearly incidence was less than 10 cases per year until 1970. When it began to increase, reaching a maximum of 78 cases in 1983.
4. Regionally Seoul had the greatest number of patients, and there was no significant difference first occurred and the present address.
5. The occupational distribution among males included office workers, 31.5%; drivers, 10.6%; laborors, 7.9%; teachers, 7.4$; engineers, 6.5%, and among females was office workers, 6.7%; labrors, 2.8%; unemployed, 81.7%.
6. Among the presumed aggrevation factors, oral ulcers and recurent tonsillitis (20.8%) were the most frequent and aggrevation of the disease occurred more frequently in the summer (8.4%).
7. Excerbation in realation to menstruation was premenstrual (12.8%), during menstruation (5.3%) and postmenstrual (4.8%).
8. The initial symptoms were oral ulcers (80.6%), skin lesions(10.3%), genitalulcer (6.3%) and eye symptoms (2.8%).
9. The average duration between the appearance of the first and second major manifestations was 5.2 years for the complete type, 6.3 years for the incomplete type and 6.3 years for the suspected type, 6.3 years for the incomplete type and 6.3 years for the suspected type.
10. The average duration of the symptoms at the time of diagnosis was 6.4 years for oral ulcer, 3.2 years for genital ulcers, 3.1 years for skin lesions and 2.6 years for eye lesions, with the oral ulcers showing the longest duration of symtoms.
11. The rate of symptom recurrence per years were for genital ulcers, 8.0 times/years for skin lesion and 4.8 times/years for eye lesions.
12. Combinations of major manifestations most commonly included oral ulcers, genital ulcers and skin lesions (65.3%) for the incomplete type, and oral ulcers and skin lesions (54.8%) for the suspected type.
13. The existence of recurrent oral ulcers of Behcet's syndrome in the families of patients with Behcet;s syndrom was 10.0% for mothers, 7.7% for siblings, 5.2% for fathers and 1.4% for partners.