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마우스의 조건회피 반응에 대한 향정신성 및 단백억제성 약물의 영향

Other Titles
 Effect of psychotropics and protein synthesis inhibitors on the conditioned avoidance response in mice 
Issue Date
1982
Description
의학과/석사
Abstract
[한글] 동물은 환경변화에 다양한 반응으로 적응하게 되며 적응능력의 기초가 되는 학습에 의한 기억은 후천적으로 환경에 노출되어 얻은 감각이 신경전달로를 통하여 대뇌피질에서 저장 재생되는 것으로 알려져 있다. 기억은 습득한 지 얼마되지 않은 불안정한 단기기억과 세포의 구조적 변화로 얻어진 안정된 장기기억으로 나뉘며 이 두가지 기억이 동일기전으로 일어나는 지 또는 다른 기전이 개재하는 지는 확실하지 않다. 그러므로 본 실험에서는 마우스의 조건회피반응에 대한 약물의 영향을 관찰하기 위하여 향정신성약물로 major tranquilizer인 chlorpromazine, 중추신경흥분제인 amphetamine 및 caffeine, 단백합성억제성 항생제인 chloramphenicol과 항암제인 cyclophosphamide를 써서 조건회피반응의 수행시간으로 학습에 의한 기억에 미치는 영향을 관찰하여 다음과 같은 결론을 얻었다. 1. 마우스를 학습시키면 2일이후 도피시간의 급격한 단축을 보이며 그 이후는 일정한 도피시간을 유지하였다. 오전과 오후 학습에 있어서 큰 차이는 없었으나 오후에 학습능력이 향상되는 경향을 보였다. 2. 6일간 학습시킨 마우스에 cyclophosphamide chloramphenicol을 투여하여서는 도피시 간단축에 큰 변동을 관찰할 수 없었다. 3. 중추신경억제제인 chlorpromazine은 학습에 의한 도피시간의 단축효과를 지연시켰고 중추신경흥분제인 amphetamine 및 caffeine은 학습에 의한 도피시간을 현저히 단축시켰다. 이상의 결과로 보아 중추신경억제제는 조건회피반응으로 관찰한 학습능력을 저하시키고 중추신경흥분제는 학습능력을 향상시켰으며 이미 형성된 기억에 대하여 단백합성억제제의 단기간투여는 아무 영향을 주지 못함을 알 수 있었다. Effect of psychotropics and protein synthesis inhibitors on the conditioned avoidance response in mice Hyung Ken Chung, M.D. Department of Medical Science The Graduate School Yonsei University (Directed by Professor Sa Suk Hong, M.D.) Momory may be defined as the storage and retrieval of the sensory information and it is commonly accepted that the formation of the memory shows at least four stages; the acquisition, the short term memory, the consolidation and the long term memory. Many investigators refer the short term memory which is linked to the reverbratory circuits and which may be ablated by coma, anesthesia or electroconvulsive therapy. Long term memory refers to the consolidation of the information with long term storage and has been suggested to invelve protein synthesis. This experiment was done to study the influence of psychotropics and the protein synthesis inhibitors on the conditioned avoidance response in mace. The conditioned avoidance response was measured in mice using the shuttle box. The mice were trained 6 times daily for 6 days and then the effect of cyclophoshamide, (0.1 ㎎/㎏) or chloramphenicol (50 ㎎/㎏) on the conditiones avoidande responses time was measured two triale (morning and afternoon)daily for 5 days. The conditioned avoidance response time in the mice injected chlorpromazine (0.1 ㎎/㎏), amphetamine (0.25 ㎎/㎏) or caffeine (0.5 ㎎/㎏) was determined two times after drug administration. The results are summarized as follows; 1. The normal mice acquired the conditioned avoidance response slowly during the first two days of training and remained relatively stable thereafter for 4 days, and the conditioned avoidance response time was slightly shorter in the afternoon. 2. Treatment of the protein synthesis inhibitors, such as cyclophosphamide and chloramphenicol, caused no significant influence in the response time in the mice trained for 6 days. 3. The cholrpromazine treatment prolonged the avoidance response time, but amphetamine and caffeine treated group showed marked shortening of the response time. In view of these results, it is presumed that the acquisition and the retrieval of the learning is accelerated by CNS stimulants and decelerated by CNS depressants. The protein synthesis inhibitors has little effects on the previousely formed learning.
[영문] Momory may be defined as the storage and retrieval of the sensory information and it is commonly accepted that the formation of the memory shows at least four stages; the acquisition, the short term memory, the consolidation and the long term memory. Many investigators refer the short term memory which is linked to the reverbratory circuits and which may be ablated by coma, anesthesia or electroconvulsive therapy. Long term memory refers to the consolidation of the information with long term storage and has been suggested to invelve protein synthesis. This experiment was done to study the influence of psychotropics and the protein synthesis inhibitors on the conditioned avoidance response in mace. The conditioned avoidance response was measured in mice using the shuttle box. The mice were trained 6 times daily for 6 days and then the effect of cyclophoshamide, (0.1 ㎎/㎏) or chloramphenicol (50 ㎎/㎏) on the conditiones avoidande responses time was measured two triale (morning and afternoon)daily for 5 days. The conditioned avoidance response time in the mice injected chlorpromazine (0.1 ㎎/㎏), amphetamine (0.25 ㎎/㎏) or caffeine (0.5 ㎎/㎏) was determined two times after drug administration. The results are summarized as follows; 1. The normal mice acquired the conditioned avoidance response slowly during the first two days of training and remained relatively stable thereafter for 4 days, and the conditioned avoidance response time was slightly shorter in the afternoon. 2. Treatment of the protein synthesis inhibitors, such as cyclophosphamide and chloramphenicol, caused no significant influence in the response time in the mice trained for 6 days. 3. The cholrpromazine treatment prolonged the avoidance response time, but amphetamine and caffeine treated group showed marked shortening of the response time. In view of these results, it is presumed that the acquisition and the retrieval of the learning is accelerated by CNS stimulants and decelerated by CNS depressants. The protein synthesis inhibitors has little effects on the previousely formed learning.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/117001
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 석사
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