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Halothane이 흰쥐간에 미치는 영향에 관한 조직학적 연구

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 Histopathological changes in the rat liver after halothane anesthesia 
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Halothane은 1951 ∼ 1956년 사이에 Suckling에 의해 합성 된 이래 본 마취제는 그 우수성이 인정되어 임상에 널리 사용되있다. 그러나 halothane 마취후 독성간염의 발생은 많은 논대상이 되어 왔다. 저자는 halothane 마처후에 간손상의 여규명하는 과정으로서 횐쥐 66마리를 사용하여 halothane 따른 조직학적 변화를 조사하여 다음과 같은 결론을 얻었다.

1. 정상대조군 및 Phenobarbital 투여군에서는 특이한 조직학적 변화를 볼 수 없었다.

2. Halothane 마취군, phenobarbital 전처치후 Halothane 마취군, Hypoxia군, hypoxia하에 Halothane 마취군에서는 마취 후 간의 조직학적 변화를 볼 수 있었으며 손상정도 역시 phenobarbital 전처치나 hypoxia하에서 심하였으며 phenobarbitalv 전처치후 hypoxia

하에 halothane 마취를 시행한 군에서는 부분적 간 괴사 현상을 볼 수 있었다.

이상의 소견으로 보아 흰쥐에서 halothane은 phenobarbital 전처치나 hypoxia 하에서 간의 손상을 미칠수 있는 것으로 생각된다.


1. Introduction

Sometime during 195l and 1956, halothane was synthestzed by Suckling as the possible ideal anesthetic. It has been, and still is the most widely used Inhalation anesthetic agent. Halothane induced hepatic injury has been very rare, and the etiology unknown. The present investigation is aimed at relationship between halothane anesthesia and hepatic injury

2. Materials and Methods

a) Sixty six rats weighing about 200gm each were divided into 7 groups :

Ⅰ. Control group

Ⅱ. Phenobarbital treated group

Ⅲ. Group that received halothane anesthesia

Ⅳ. Group that received halothane anesthesia after phenobabital pretreatment

Ⅴ. Hypoxia group

Ⅵ. Group that received halothane anesthesia under hypoxia

Ⅶ. Group that received halothane anesthesia under hypoxia after phenobarbital pretreatment.

b) 24 hours after anestheslal the animals were sacrificed andspecimens of lover obtained

c) The slides of each section were stained with HematoxyInEosin and Periodic Acid-Schiff stain

d) Microscopic examinations were performed

3. Results

a) In groups Ⅰ and Ⅱ, specific pathological changes were absent

b) In groups Ⅲ, Ⅳ, Ⅴ, Ⅵ and Ⅶ, specific pathological changes such as cellular swelling, vacuole formation in cytoplasm, inflammatory cell infiltration or focal necroais were visible with H-E stain. Such Pathological Changes were more

sever in groups with phenobarbital pretreatment and/or hypoxia .

Therefore, we can predict that the liver is damaged by halothane in case of phenobarbital pretreatment and/or hypoxic condition.
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