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향정신성 약물이 Mouse의 자발운동에 미치는 영향

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 Effects of psychotropic agents on motor activity in mice 
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[한글] 동물은 새로운 환경에 들어가면 몸단장 정위운동등의 복잡한 행동양상을 나타내는데 이것은 홀몬분비, 신경전달물질의 정도, 약물등의 외인적 또는 내인적인 요소들에 의해 커다란 영향을 받는다. 향정신성약물이 동물의 행동에 미치는 영향을 정량적으로 검색하기 위하여 여러방법이 고안되었고 가장 보편화된 것이 광전판을 이용한 것이다. 그것은 공명회로의 원리를 이용하여 동물이 전장으로 들어오면 공평회로의 변화를 일으켜 숫자판에 기록된다. 근래에 소개된 자발운동 측정계기로 Columbus Instruments에서 제조한 Selective activity meter가 있다. 본 실험은 수종의 향정신성 약물이 mouse의 자발운동에 미치는 영향을 검색하였다. 6개의 전자회선으로 덮힌 계기 위에 plastic 상자를 놓고 그 안에 mouse 5마리를 넣어 시행하였다. 각 실험군은 chlorpromazine 10mg/kg, haloperidol 1mg/kg, diazepam 5mg/kg, meprobamate 100mg/kg, imipramine 25mg/kg, amphetamine 2.5mg/kg 투여군과 생리적 식염수 투여 대조군으로 나누었고 각 군마다 5회 이상씩 반복 실험하였다. 자발운동은 약물 투여후 10분, 20분, 30분, 60분, 90분, 120분에 기록하였다. 결론은 다음과 같다. 1. Chlorpromazine은 major tranquilizer로 mouse의 자발운동을 대조군에 비해 현저하게 저하시키며 90분 이후의 감소율은 타 실험약물을 보다 현저하였다. haloperidol 투여군도 chlorpromazine 투여군과 비슷한 자발운동저하를 나타냈으나 90분 이후에는 다소 증가하는 경향을 보여주었다. 2. Diazepam은 minor tranquilizer로 자발운동 억제는 대조군에 비해 30분에 현저하게 저하되었으나 90분 이후에는 chlorpromazine 투여군 보다 다소 증가하였다. meprobamate는 chlorpromazine이나 haloperidol 투여군과 같이 mouse의 자발운동을 현저하게 억제한 다. 그러나 diazepam 투여군 보다는 덜 억제시켰다. 3. 항우울제인 imipramine은 대조군에 비해 10분에서는 자발운동이 억제되지 않았으나 그 이후에는 점차 억제되었다. 4. Amphetamine은 중추신경 흥분제이지만 약물투여 후 30분까지 자발운동의 특별한 증가를 보여주지 않았다. 그러나 그 이후에는 현저하게 증가하였다.
[영문] An animal which is placed in a new environment displays a complex behavioral pattern consisting of locomotion, grooming and rearing. This behavioral pattern is influenced by endogenous and exogenous stimuli, such as hormonal secretion, level of neurohumoral transmitters, drugs and light. It is widely known that the most tranquilizers depressed spontaneous motor activity although their mechanisms of action were different, while antidepressants stimulated except imipramine which showed various action. Until the present time, the hole-board apparatus, which gives rather subjective data, has been used extensively to study the effects of drugs on general activity and exploratory behavior in mice. Recently a new apparatus for mobility measurements, called a "Selective Activity Meter" has been introduced by Columbus Instrument Company. This instrument supposedly produces more objective data on activity and behavior. The purpose of the present experiment was to study the influence of psychotropics on motor activity using the Selective Activity Meter. In the experiment, various psychotropic agents such as major tranquilizers (chlorpromazine, haloperidol): minor tranquilizers (meprobamate, diazepam): and antidepressants (amphetamine, imipramine) were used. In each experiment, the drug was administered to five mice and their activity was recorded. Each experiment was run five or more times and the results are based on the mean of each trial. The results are summarized as follows: 1. The group of mice treated with chlorpromazine showed markedly inhibited motor activity in comparison with controls and the inhibitory action of chlorpromazine was shown to be more intense than any of the other drugs used in the test. Haloperidol administration yielded similar results until 60 minutes, but mice showed less inhibition of motor activity than with chlorpromazine after 90 minutes. 2. In the group treated with diazepam, there was strong inhibition of motor activity until 30 minutes, but after 60 minutes the mice showed less inhibition than with chlorpromazine. In the meprobamate group, motor activity was inhibited in a manner similar to that of other tranquilizers. but the inhibition was less than that of diazepam. 3. In the group treated with imipramine, the inhibition developed gradually after ten minutes. 4. The effects of amphetamine did not appear until 30 minutes after administration, but then there was a significant increase in the motor activity.
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2. Thesis / Dissertation (학위논문) > 1. College of Medicine (의과대학) > Master's Degree (석사)
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