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위분비기능에 대한 아드레나린성 영향

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 Adrenergic influence on gastric secretion in the pylorus-ligated rats 
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[한글]위산분비는 주로 자율신경계, 위·장홀몬, histamine등 국소홀몬 및 순환계의 영향을 받고 있다. 자율신경계의 부교감신경계에 대한 검색은 많으나 교감신경계에 대한 검색은 그렇지 못하여 그 중요성도 아직 인식되지 못하고 위분비기능에 미치는 효과에 대해서도 정설이 없는 실정이다. 이번 실험에서는 내인성 catecholamine인 norepinephrine, epinephrine, dopamine과 아드레나린성 a-수용체 효현제인 methoxamine, β-수용체 효현제인 isoproterenol을 Shay rat에 투여하여 위분비기능에 대한 아드레나린성 영향을 검색하여 다음의 결과를 얻었다. 1. 유문부결찰로 인한 시간당 위액, 위산 및 pepsin의 기초분비는 3시간까지 활발하고 그 후에는 미약하였다. 2. 아드레나린성 약물투여군 모두에서 위액 및 위산분비 억압이 관찰되었는데, epinephrine과 isoproterenol의 효과가 가장 현저하였고 methoxamine과 norepinephrine은 중등도의, dopamine은 가장 약한 억압효과를 나타내었다. 3. 혈중 glucose 농도는 아드레나린성 약물의 위분비 억압작용과 직접적인 관련이 없었다. 이상의 성적으로 보아 위분비기능에 대하여 아드레나린성 영향은 억제성으로 작용하고 특히 α-수용체보다는 β-수용체 자극이 강한 억압효과를 나타냄을 알 수 있었다.
[영문]Gastric secretion is modulated largely by three major factors-the autonomic nervous system, the gastrointestinal hormones and the circulation. For autonomic nervous system, the parasympathetic influence on gastric secretion has been widely studied. However, the influence of sympatho-adenal system has received much less attention and its role on gastric secretion remains a matter of controversy. Present investigation was undertaken to evaluate the adrenergic influence on gastric secretion using the experimental model of pylorus-ligated rat. Immediately after pylorus ligation intrinsic or synthetic adrenergic agents (methoxamine, norepine-phrine, epinephrine, isoproterenol or dopamine) were injected subcutaneously. After 3- or 6-hour period of pyloric ligation the stomach was removed and gastric juice was collected for the evaluation of gastric secretory function, And blood glucose level was also measured. The results obtained are as follows. 1. Gastric secretory function was active in the group of 3 hours pyloric-ligation and depressed greatly thereafter. 2. All adrenergic drugs used in this experiment suppressed the volume of gastric juice and acid output. The degree of suppression was marked in epinephrine or isoproterenol, moderate in methoxamine or norepinephrine and minimal in dopamine treated rats. 3. Blood glucose level was not directly correlated with the suppressive action of adrenergic drugs on gastric secretion. From the above results it is concluded that gastric secretory function is suppressed by adrenergic influence. And it is suggested that adrenergic β-receptor activation plays major role in the suppression of gastric secretion.
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