Walker Carcinosarcoma 256의 골이식에 관한 실험적 연구

Abstract

[한글]

[영문]Bone tumors in Orthopedic Surgery, have been studies recently by many authors.

One of the big problems is that even though there are many methods of treatment, the result are not satisfactory and a good prognosis can not be expected without the use of specific auticancer drugs. Therefore, experimental transplantation of bone tumor is very important as a fundamental study for further investigation of cancer problems.

Many experimental transplantations have been done in the field of Orthopedic Surgery subcutaneously intramuscularly and intramedullary, but we can not find any experimental reports about subperiosteal and parosteal trasplantation of tumor cells. We transplanted the Walker Carcinosarcoma 265 intramedullary (Group Ⅰ), subperiosteally (Group Ⅱ) and parosteally (Group Ⅲ) into the distal portion of the right femur of white rats.

The result are as follows :

1. Transplantation rate is

a. within 2 hours b. between 3-4 hours

Group Ⅰ : 87.5 % Group Ⅰ : 44.4%

Group Ⅱ : 78.6 % Group Ⅱ : 80.0%

Group Ⅲ : 93.6 % Group Ⅲ : 80.0%

2. Palpable tumor mass was initially found

Group Ⅰ : 9 - 12 days

Group Ⅱ : 6 - 9 days

Group Ⅲ : 6 - 7 days

3. Body weight was increased in all experimental groups after 17 - 22 dayscompared with the control group which was due to increasing of tumor mass.

4. Anemia developed markedly in Group Ⅰ after 12 days and Group Ⅱ after 15 days but slightly in Group Ⅲ. WBC count was markedly elevated in Group Ⅰ after 12 days and Group Ⅱ after 21 days but developed after and lesser degree in Group Ⅲ.

5. In X-ray studies, destructive bone change4s and periosteal reaction was noted in Group Ⅰ at 12 days and some periosteal reaction was noted in small numbers of Group Ⅱ at 21 days but no bone change or periosteal reaction could be found in Group Ⅲ.

6. All experimental transplanted tumors were confirmed histopathologically. Carcinomatous pattern was more predominant in Group Ⅰ and Ⅱ, and Sarcomatous pattern