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Diethyl Ether 마취의 실험적 연구

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 Experimental study on diethyl ether anesthesia 
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[영문] Diethyl ether was first described by Valerius Cordus in 1540, and it is generally agreed that Crawford Long used ether for 3 surgical patients in 1842, and Morton subsequently gave a definitive public demonstration in Boston in October, 1846. After this, ether used became widely published and the news spread to London, where Drs. Boot and Squires soon used it on surgical cases at University College Hospital. The importance and volume of diethyl other in the anesthesia field grew day by day and year by year after Crawford Long and Morton, and it is widely used by various techniques. But, during the past decade, the frequency of usage of diethyl ether has declined and it is now hard to find new articles on diethyl ether. The reason is that the experience of induction is most unpleasant and stormy with secretions, vomiting and laryngospas also, excessive depth is often produced and in the post operative course, headache, nausea, vomiting, and fluid or electrolyte disorders may follow. Another reason is the production of various new inhalation anesthetics. Today, many serious complications of new anesthetics are report especially halothane may have a hepato-sensitive effect (Burnap 1958 Virtus 1958, Barton 1959, Temple 1962, and Bunker 1963), and new recent articles about ether were published by McArdle (1968), Oyama (1969) and Markello (1969). It should also be remembered that, although its use in clinical practice in Britain and other western parts is now almost as limited as chloroform, ether is still the main inhalational anesthetic in many parts of the world, because diethyl ether is an excellent anesthetic safer and perhaps more inexpensive than any other. since diethyl ether has recently been produced in Korea, objectives of the study were mainly reevaluation of the effects of diethyl ether through experimental animal studies. Nine healthy normal dogs weighing approximately 10 kg. body weight were employed in this experiment and 4 dogs anesthetized with Squibb ether and 5 dogs with Korea made ether, were used for the study. Endotrachcal intubation was done under light sedation with pentobarbital sodium 30 mg/kg I.V. and the tube connected with a Ruben valve; Nonrebreathing system which could be applied 023 to 0.5L/min. through the Heidbrink Ohio Chemical Anesthesia Aparatus without any anesthetics. Cannulations were applied into the right jugular vein for C.V.P, into the femoral artery for arterial pressure, the femoral vein for fluid infusion which contained Inulin and B.S.P. (priming doses were 50mg/kg and 5mg/kg and maintenance doses were 0.25mg/kg/min. and 0.05mg/kg/min.) using the Harvard infusion pump (2 ml/min.), the other femoral artery for blood sampling, both ureters for urine collection, and the common bile duct for bile collection. A Polygraph Grass Type 4 Channel Machine was connected for E.E.G., E.C.G,, C.V.P. and arterial pressure. During the whole of the study, E.E.G., E.C.G., arterial pressure, C.V.P. and arterial blood sampling for PaCO^^2, PaO^^2, pH and hemoglobin, and urine collection for Inulin clearance, and bile collection for B.S.P. clearance, was done every 20 minutes through a 4 hours (one hour for the pre-anesthetic period, two hours for the anesthesia period, and one hour for the post-anesthetic period). Arterial blood gas, and pH were analyzed with a Radiometer, hemoglobin by the hemophotometer, Inulin clearance by the Schreiner method, and B.S.P. clearance by the Pitt aceton method. After the post-anesthetic period, tissue specimens; the heart, lung, liver and kidney, were fixed in 10% formalin and stained with hematoxylin and eosin, and PAS. stain for histopathological study. Result and Summary An E.C.G. tracing with pulse rate, arterial pressure, and C.V.P. were not changed significantly during ether anesthesia in dogs. Within the first 60 minutes during other anesthesia, PaO^^2 were elevated but after that gradually declined until post-anesthetic period. PaCO^^2, pH and hemoglobin values did not show any remarkable change in all experiments. B.S.P. and Inulin clearances during ether anesthesia were decreased but recovered slightly in the post-anesthetic period. Histopathologically, in a few dogs, a slight alveolar edema, capillary congestion, alveolar wall thickening, mucosal degeneration, destruction of bronchioles in the lung and glomcrular ischemic changes in the kidney were observe. No other pathological findings in the heart and liver were found.
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2. Thesis / Dissertation (학위논문) > 1. College of Medicine (의과대학) > Master's Degree (석사)
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