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A Pilot Study of Trans-Arterial Injection of 166Holmium-Chitosan Complex for Treatment of Small Hepatocellular Carcinoma

DC FieldValueLanguage
dc.contributor.author김주항-
dc.contributor.author노재경-
dc.contributor.author손주혁-
dc.contributor.author안중배-
dc.contributor.author유내춘-
dc.contributor.author이종두-
dc.contributor.author이종태-
dc.contributor.author정현철-
dc.contributor.author조병철-
dc.contributor.author최혜진-
dc.date.accessioned2015-08-26T16:39:13Z-
dc.date.available2015-08-26T16:39:13Z-
dc.date.issued2005-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/114853-
dc.description.abstractPercutaneous approaches, such as percutaneous ethanol injection and radiofrequency ablation, have been most widely used for hepatocellular carcinoma patients who were not eligible for surgery. New technologies to improve the efficacy are currently needed. 166Holmium is a neutron activated radionuclide, and has several beneficial radiophysical characteristics for internal radiation therapy. 166Holmium-Chitosan complex, in which chitosan is chelated with 166Holmium, was developed as a radiopharmaceutical for cancer therapy. We have conducted a pilot study to evaluate the clinical efficacy of transarterial administration of 166Holmium-Chitosan complex in patients with a single and small (< 3 cm) hepatocellular carcinoma. 166Holmium-Chitosan complex, at a dose of 20 mCi per cm of tumor mass-diameter, was administered through the artery that directly fed the tumor. Twelve patients were treated with a median follow-up duration of 26 (range: 12-61) months. The tumor diameter ranged between 1.5 and 2.5 cm. Ten patients (83%) had complete response and two (17%) had partial response. The median complete response duration was not reached. The median AFP level declined from 83.8 to 8.3 ng/mL within 2 months after treatment. No grade III/IV toxicity was observed. Grade I and II toxicities were observed in four patients (2 abdominal pain, 1 fever, and 1 AST/ALT elevation). No toxic death occurred. This preliminary study shows a promising and durable complete response rate with an acceptable safety profile. Further studies with greater accrual of patients are warranted.-
dc.description.statementOfResponsibilityopen-
dc.format.extent799~805-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Hepatocellular/diagnostic imaging-
dc.subject.MESHCarcinoma, Hepatocellular/pathology-
dc.subject.MESHCarcinoma, Hepatocellular/radiotherapy*-
dc.subject.MESHChitosan/administration & dosage-
dc.subject.MESHChitosan/therapeutic use*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInjections, Intra-Arterial-
dc.subject.MESHLiver Neoplasms/diagnostic imaging-
dc.subject.MESHLiver Neoplasms/pathology-
dc.subject.MESHLiver Neoplasms/radiotherapy*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPilot Projects-
dc.subject.MESHRadiopharmaceuticals/administration & dosage-
dc.subject.MESHRadiopharmaceuticals/therapeutic use*-
dc.subject.MESHTomography, X-Ray Computed-
dc.subject.MESHalpha-Fetoproteins/metabolism-
dc.titleA Pilot Study of Trans-Arterial Injection of 166Holmium-Chitosan Complex for Treatment of Small Hepatocellular Carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorByoung Chul Cho-
dc.contributor.googleauthorEun Hee Kim-
dc.contributor.googleauthorJoo Hyuk Sohn-
dc.contributor.googleauthorNae Choon Yoo-
dc.contributor.googleauthorJong Tae Lee-
dc.contributor.googleauthorJong Doo Lee-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorJae Kyung Roh-
dc.contributor.googleauthorJoo Hang Kim-
dc.contributor.googleauthorHye Jin Choi-
dc.identifier.doi10.3349/ymj.2005.46.6.799-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00945-
dc.contributor.localIdA01290-
dc.contributor.localIdA01995-
dc.contributor.localIdA02262-
dc.contributor.localIdA02457-
dc.contributor.localIdA03138-
dc.contributor.localIdA03150-
dc.contributor.localIdA03773-
dc.contributor.localIdA03822-
dc.contributor.localIdA04219-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid16385656-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keyword166Holmium-chitosan complex-
dc.subject.keywordtrans-arterial-
dc.subject.keywordinternal radiation therapy-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameRoh, Jae Kyung-
dc.contributor.alternativeNameSohn, Joo Hyuk-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameYoo, Nae Choon-
dc.contributor.alternativeNameLee, Jong Doo-
dc.contributor.alternativeNameLee, Jong Tae-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameCho, Byoung Chul-
dc.contributor.alternativeNameChoi, Hye Jin-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorRoh, Jae Kyung-
dc.contributor.affiliatedAuthorSohn, Joo Hyuk-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorYoo, Nae Choon-
dc.contributor.affiliatedAuthorLee, Jong Doo-
dc.contributor.affiliatedAuthorLee, Jong Tae-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorCho, Byoung Chul-
dc.contributor.affiliatedAuthorChoi, Hye Jin-
dc.rights.accessRightsfree-
dc.citation.volume46-
dc.citation.number6-
dc.citation.startPage799-
dc.citation.endPage805-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.46(6) : 799-805, 2005-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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