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The variation of biomechanical property of chondrocyte under the various biological conditions

Authors
 Park Sang-Guk  ;  Lee Kwon-Yong  ;  Lee Heayoung  ;  Lee Inseop  ;  Park Jong-Chul  ;  Shin Daehwan 
Citation
 CURRENT APPLIED PHYSICS, Vol.5(5) : 493-496, 2005 
Journal Title
 CURRENT APPLIED PHYSICS 
ISSN
 1567-1739 
Issue Date
2005
MeSH
Articular cartilage ; Chondrocyte ; Young’s modulus ; Extra cellular matrix ; Cytoindentation
Keywords
Articular cartilage ; Chondrocyte ; Young’s modulus ; Extra cellular matrix ; Cytoindentation
Abstract
It has been reported that mechanical properties of tissue-engineered cartilage were significantly lower than those of natural cartilage, even though many efforts have been made to regenerate high quality articular cartilage by tissue engineering techniques. Further studies must be conducted to find an optimal technique for regeneration of qualitative cartilage with the type of cells, extracellular matrices, growth factors, scaffolds, and bioreactors providing a proper mechanical stimulation. In this study, the effects of culture time and three different kinds of extra cellular matrixes (ECM) in two levels of density on the variation of stiffness (Young’s modulus, E) of chondrocyte were evaluated by the cytoindentation technique. Compared with no ECM coating, all kinds of ECM coatings improved Young’s modulus of chondrocyte. Type II collagen and fibronectin significantly increased the Young’s modulus of chondrocyte after 4 h culture time. This suggested that the variations of biological environment affected the biomechanical property of chondrocyte. This result provided the valuable information to tissue engineering approaches for obtaining more improved biomechanical property of regenerated cartilage tissue.
Full Text
http://www.sciencedirect.com/science/article/pii/S1567173905000234
DOI
10.1016/j.cap.2005.01.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114808
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