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An antioxidant system required for host protection against gut infection in Drosophila

Authors
 Eun-Mi Ha  ;  Chun-Taek Oh  ;  Won-Jae Lee  ;  Paul T. Brey  ;  In-hwan Jang  ;  Sang-Won Kang  ;  Yun-Soo Bae  ;  Ji-Hwan Ryu 
Citation
 DEVELOPMENTAL CELL, Vol.8(1) : 125-132, 2005 
Journal Title
 DEVELOPMENTAL CELL 
ISSN
 1534-5807 
Issue Date
2005
MeSH
Animals ; Animals, Genetically Modified ; Antioxidants/physiology* ; Bacteria/pathogenicity ; Bacterial Infections/immunology ; Bacterial Infections/prevention & control* ; Blotting, Western/methods ; Catalase/physiology* ; Cell Line ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drosophila ; Drosophila Proteins/physiology* ; Gastrointestinal Tract/microbiology* ; Gene Expression Regulation, Enzymologic/physiology ; Green Fluorescent Proteins/metabolism ; Hydrogen Peroxide/pharmacology ; Immunity, Innate/physiology* ; NF-kappa B/physiology ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; RNA Interference/physiology ; Recombinant Proteins/metabolism ; Time Factors ; Transfection/methods
Keywords
15621536
Abstract
A fundamental question that applies to all organisms is how barrier epithelia efficiently manage continuous contact with microorganisms. Here, we show that in Drosophila an extracellular immune-regulated catalase (IRC) mediates a key host defense system that is needed during host-microbe interaction in the gastrointestinal tract. Strikingly, adult flies with severely reduced IRC expression show high mortality rates even after simple ingestion of microbe-contaminated foods. However, despite the central role that the NF-κB pathway plays in eliciting antimicrobial responses, NF-κB pathway mutant flies are totally resistant to such infections. These results imply that homeostasis of redox balance by IRC is one of the most critical factors affecting host survival during continuous host-microbe interaction in the gastrointestinal tract.
Full Text
http://www.sciencedirect.com/science/article/pii/S1534580704004058
DOI
10.1016/j.devcel.2004.11.007
Appears in Collections:
5. Research Institutes (연구소) > Research Center for Human Natural Defense System (생체방어연구센터) > 1. Journal Papers
Yonsei Authors
Ryu, Ji Hwan(유지환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114807
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