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Dynamic expression pattern of Hoxc8 during mouse early embryogenesis

Authors
 Yunjeong Kwon  ;  Jaeseung Shin  ;  Myoung Hee Kim  ;  Hyoung Woo Park 
Citation
 ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, Vol.283A(1) : 187-192, 2005 
Journal Title
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
ISSN
 1932-8486 
Issue Date
2005
MeSH
Animals ; Cell Differentiation ; Embryonic Development/physiology* ; Gene Expression Regulation, Developmental* ; Gestational Age ; Homeodomain Proteins/metabolism* ; In Situ Hybridization ; Mice ; Mice, Inbred ICR ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
Keywords
Hoxc8 ; murine embryo ; whole-mount in situ hybridization ; expression pattern
Abstract
The Hoxc8 expression pattern was examined in mouse embryos 7.5–12.5 days postcoitum (dpc) using whole-mount in situ hybridization and RT-PCR. The expression of Hoxc8 started between 7.5 and 8.5 dpc. A strong expression was detected in the ectoderm and mesoderm at 8.5 dpc. At 9.5 dpc, a distinct anterior boundary of Hoxc8 expression was established at the 10th and 16th somites in the neural tube and the paraxial mesoderm, respectively. This staggered expression pattern was maintained throughout the later stages. By 12.5 dpc, the forward progression of the Hoxc8 expression pattern was observed and the stain was weakened. In the ectoderm-derived neural tube, strong Hoxc8 expression was observed in the ventral horn and later in the ventral and mediolateral region of the mantle layer, indicating a possible association with the onset and progression of neural differentiation. In the case of the mesoderm-derivative cells, strong Hoxc8 expression was detected in the sclerotome on the way to the notochord and neural tube and mesonephros, suggesting a role of Hoxc8 in the formation of the vertebrae and ribs and the possible involvement in the differentiation into the kidney.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/ar.a.20160/abstract
DOI
10.1002/ar.a.20160
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Yunjeong(권윤정)
Kim, Myoung Hee(김명희) ORCID logo https://orcid.org/0000-0001-5652-1452
Park, Hyoung Woo(박형우) ORCID logo https://orcid.org/0000-0002-5341-9249
Shin, Jaeseung(신재승) ORCID logo https://orcid.org/0000-0002-6755-4732
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114742
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