3 387

Cited 10 times in

Effect of subthalamic lesion with kainic acid on the neuronal activities of the basal ganglia of rat parkinsonian models with 6-hydroxydopamine

Authors
 Jin Woo Chang  ;  J. S. Yang  ;  S. S. Chung  ;  B. H. Lee  ;  M. F. Jeon 
Citation
 Acta Neurochirurgica Supplements, Vol.87 : 163-168, 2003 
Journal Title
Acta Neurochirurgica Supplements
ISSN
 0065-1419 
Issue Date
2003
MeSH
6-hydroxydopamine ; parkinson's disease ; subthalamus ; basal ganglia
Keywords
6-hydroxydopamine ; parkinson's disease ; subthalamus ; basal ganglia
Abstract
The aim of the present study was to investigate the alteration of neuronal activities in the substantia nigra pars reticulata (SNpr) and globus pallidus (GP), after ipsilateral STN lesioning by kainic acid in the rat hemi-parkinsonian 6-hydroxydopamine (6-OHDA) model. In various rat Parkinson's disease (PD) models, an increase in the SNpr firing rate was observed, despite the occurrence of bursting patterns, and subthalamic lesion was found to reduce the mean firing rates and the percentage of bursting neurons in the SNpr. However, the relative proportion of bursting neurons, among all GP neurons, was slightly increased as a result of the subthalamic lesion. The significance of bursting activity in the SNpr and GP remains obscure. Further study is necessary to elucidate the pathophysiological mechanism behind Parkinson's disease.
Full Text
http://link.springer.com/chapter/10.1007/978-3-7091-6081-7_34
DOI
10.1007/978-3-7091-6081-7_34
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Chung, Sang Sup(정상섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114462
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links