3 581

Cited 10 times in

Effect of subthalamic lesion with kainic acid on the neuronal activities of the basal ganglia of rat parkinsonian models with 6-hydroxydopamine

DC Field Value Language
dc.contributor.author이배환-
dc.contributor.author장진우-
dc.contributor.author정상섭-
dc.date.accessioned2015-07-15T17:12:58Z-
dc.date.available2015-07-15T17:12:58Z-
dc.date.issued2003-
dc.identifier.issn0065-1419-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/114462-
dc.description.abstractThe aim of the present study was to investigate the alteration of neuronal activities in the substantia nigra pars reticulata (SNpr) and globus pallidus (GP), after ipsilateral STN lesioning by kainic acid in the rat hemi-parkinsonian 6-hydroxydopamine (6-OHDA) model. In various rat Parkinson's disease (PD) models, an increase in the SNpr firing rate was observed, despite the occurrence of bursting patterns, and subthalamic lesion was found to reduce the mean firing rates and the percentage of bursting neurons in the SNpr. However, the relative proportion of bursting neurons, among all GP neurons, was slightly increased as a result of the subthalamic lesion. The significance of bursting activity in the SNpr and GP remains obscure. Further study is necessary to elucidate the pathophysiological mechanism behind Parkinson's disease.-
dc.description.statementOfResponsibilityopen-
dc.format.extent163~168-
dc.relation.isPartOfActa Neurochirurgica Supplements-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESH6-hydroxydopamine-
dc.subject.MESHparkinson's disease-
dc.subject.MESHsubthalamus-
dc.subject.MESHbasal ganglia-
dc.titleEffect of subthalamic lesion with kainic acid on the neuronal activities of the basal ganglia of rat parkinsonian models with 6-hydroxydopamine-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorJin Woo Chang-
dc.contributor.googleauthorJ. S. Yang-
dc.contributor.googleauthorS. S. Chung-
dc.contributor.googleauthorB. H. Lee-
dc.contributor.googleauthorM. F. Jeon-
dc.identifier.doi10.1007/978-3-7091-6081-7_34-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02791-
dc.contributor.localIdA03484-
dc.contributor.localIdA03611-
dc.relation.journalcodeJ00019-
dc.identifier.pmid10.1007/978-3-7091-6081-7_34-
dc.identifier.urlhttp://link.springer.com/chapter/10.1007/978-3-7091-6081-7_34-
dc.subject.keyword6-hydroxydopamine-
dc.subject.keywordparkinson's disease-
dc.subject.keywordsubthalamus-
dc.subject.keywordbasal ganglia-
dc.contributor.alternativeNameLee, Bae Hwan-
dc.contributor.alternativeNameChang, Jin Woo-
dc.contributor.alternativeNameChung, Sang Sup-
dc.contributor.affiliatedAuthorLee, Bae Hwan-
dc.contributor.affiliatedAuthorChang, Jin Woo-
dc.contributor.affiliatedAuthorChung, Sang Sup-
dc.rights.accessRightsnot free-
dc.citation.volume87-
dc.citation.startPage163-
dc.citation.endPage168-
dc.identifier.bibliographicCitationActa Neurochirurgica Supplements, Vol.87 : 163-168, 2003-
dc.identifier.rimsid43862-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.