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위암 환자에서 종양표지자 검사의 의의

Other Titles
 Significance of Follow-up Examination of Tumor Markers after a Radical Gastrectomy in Gastriccancer Patients 
Authors
 김용일  ;  노성훈 
Citation
 Journal of the Korean Gastric Cancer Association (대한위암학회지), Vol.3(2) : 104-111, 2003 
Journal Title
 Journal of the Korean Gastric Cancer Association (대한위암학회지) 
ISSN
 2093-582X 
Issue Date
2003
MeSH
gastric cancer ; CEA ; CA 19-9
Keywords
gastric cancer ; CEA ; CA 19-9
Abstract
Purpose: The prognostic significance of peri-operative serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA)19-9 determination in patients with gastric cancer has been controversial. This study was performed to evaluate the significance of CEA and CA19-9 as clinical predictors of prognosis. Materials and Methods: The correlations between peri-operative serum CEA/CA19-9 levels and clinicopathologic factors were evaluated retrospectively in gastric cancer patients who had undergone curative surgery during the period from January 1995 to December 1998 at the Department of Surgery, Yonsei University College of Medicine. Results: The positive rates for CEA and CA19-9 were $17.9\%$ 수식 이미지 and $18.4\%$ 수식 이미지, respectively. The CEA positivity was related to the depth of invasion (P=0.040), lymph-node metastasis (P=0.000), and stage (P=0.001). The CA19-9 positivity was significantly related to the depth of invasion (P=0.000), lymph-node status (P=0.000), and stage (P=0.000). The positive rate of combined assay of pre-operative CEA and CA19-9 was $30.0\%$ 수식 이미지 There were statistically significant correlations with stage, depth of invasion, or degree of lymphnode metastasis in the combined assay. The survival rates according to the positivity of CEA and to the positivity of CA19-9 were clearly different (P=0.000). Conclusion: It should be stressed that even a simple blood test prior to surgery could be useful in establishing the depth of invasion, the status of lymph-node involvement, and the prognosis. For improved survival, an aggressive lymphadenectomy and adjuvant chemotherapy should be considered for patients with positive levels of pre-operative CA19- 9.
Files in This Item:
T200306699.pdf Download
DOI
OAK-2003-01276
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114436
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