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A Case of Paraneoplastic Nephrotic Syndrome in a Patient with Ovarian Carcinoma

 Yong Tai Kim  ;  Sun Young Rha  ;  Jae Kyung Roh  ;  Byung Soo Kim  ;  Dae Suk Han  ;  Joo Hang Kim  ;  Hyun Cheol Chung  ;  Nae Choon Yu  ;  Chul Kim  ;  Joo Hyuk Sohn  ;  Chi Young Shim 
 YONSEI MEDICAL JOURNAL, Vol.44(3) : 539-543, 2003 
Journal Title
Issue Date
Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma/complications* ; Carcinoma/diagnosis ; Carcinoma/drug therapy ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Nephrotic Syndrome/complications* ; Nephrotic Syndrome/drug therapy ; Ovarian Neoplasms/complications* ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/drug therapy ; Paraneoplastic Syndromes/complications* ; Paraneoplastic Syndromes/drug therapy ; Remission Induction ; Tomography, Emission-Computed ; Tomography, X-Ray Computed
Paraneoplastic syndrome ; nephrotic syndrome ; ovarian carcinoma
Nephrotic syndrome is a rare manifestation of malignancy associated with paraneoplastic syndrome.

Paraneoplastic nephrotic syndrome has been reported in various malignancies: malignant lymphoma, colon cancer, lung cancer and prostate cancer. However, an ovarian carcinoma associated with nephrotic syndrome has rarely been reported. Only six cases of ovarian carcinoma associated paraneoplastic nephrotic syndrome has been reported worldwide, but no cases have been reported in Korea. Here, we report a case of paraneoplastic nephrotic syndrome in a patient with an ovarian carcinoma. The patient presented with ascites, proteinuria and hypoalbuminemia. An initial computed tomography (CT) scan and ultrasonography evaluations showed no specific findings suggestive of an ovarian tumor. Despite treatment for nephrotic syndrome, the symptoms became more aggravated. There after, follow up evaluation at Yonsei University Medical Center, including serum CA 125, pelvis MRI and peritoneal fluid examination were performed. On the pelvis MRI, a left ovarian mass was detected with an ascitic fluid collection. The serum CA 125 level was elevated to 2211 U/ml. The peritoneal fluid cytological examination showed malignant cells suggestive of an ovarian carcinoma.

Combination chemotherapies including paclitaxel plus carboplatin, topotecan plus gemcitabine and oxaliplatin plus capecitabine were administered to the patient, and complete remission was achieved on image and tumor marker studies. There was complete recovery from the nephrotic syndrome with no evidence of ascites and proteinuria. These findings suggest that nephrotic syndrome caused by paraneoplastic syndrome can be resolved only after the complete control of the underlying malignancy.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Tai(김용태)
Kim, Joo Hang(김주항)
Kim, Cheol(김철)
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Sohn, Joo Hyuk(손주혁) ORCID logo https://orcid.org/0000-0002-2303-2764
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Yoo, Nae Choon(유내춘)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Han, Dae Suk(한대석)
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