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Effect of staphylococcal enterotoxin B on specific antibody production in children with atopic dermatitis.

Authors
 Sohn, Myung Hyun  ;  Kim, Cheol Hong  ;  Kim, Kyu-Earn  ;  Jang, Gwang Cheon  ;  Kim, Woo Kyung 
Citation
 ALLERGY AND ASTHMA PROCEEDINGS, Vol.24(1) : 67-71, 2003 
Journal Title
 ALLERGY AND ASTHMA PROCEEDINGS 
ISSN
 1088-5412 
Issue Date
2003
MeSH
Adolescent ; Age Factors ; Antibody Formation/immunology* ; Antibody Specificity/immunology ; Child ; Child Welfare ; Child, Preschool ; Dermatitis, Atopic/blood* ; Dermatitis, Atopic/immunology* ; Enterotoxins/immunology* ; Enterotoxins/pharmacology* ; Female ; Humans ; Immunoglobulin E/blood ; Immunoglobulin E/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunoglobulin M/blood ; Immunoglobulin M/immunology ; Infant ; Infant Welfare ; Male ; Sensitivity and Specificity ; Severity of Illness Index ; Treatment Outcome
Keywords
12635580
Abstract
Exotoxins secreted by Staphylococcus aureus have been identified as a possible trigger factor in atopic dermatitis (AD). We investigated the production and role of circulating antibodies, with specificity to staphylococcal enterotoxin B (SEB), in children with AD compared with those of healthy controls. The children with AD had significantly higher levels of serum SEB-specific immunoglobulin G (IgG; p = 0.0193), IgM (p = 0.011), and IgE (p = 0.0001) than the nonatopic children. The proportions of IgG, IgM, and IgE seropositivity in children with AD were 52.5% (21/40), 62.5% (25/40), and 67.5% (27/40), respectively. The levels of SEB-specific IgE and the severity of AD (p = 0.0004) were compared, but no correlation was seen for IgG or IgM. SEB may be involved in exacerbation of AD. SEB-specific IgE may be an important index of the clinical severity of AD. The SEB-specific IgG or IgM was produced during the exposure to the SEB antigen but may not be protective against SEB in AD.
Full Text
http://www.ingentaconnect.com/content/ocean/aap/2003/00000024/00000001/art00010?token=0055173cea1a5bd275c277b42572b6756766b256245744a6d592f653b643d437c4e724770e9b991cd7a7a
DOI
OAK-2003-01091
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyu Earn(김규언)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114251
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