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미만성 스텐트 내 재협착에 대한 Cutting Balloon 관동맥 성형술과 Holmium 풍선도자를 이용한 방사선 근접치료

Other Titles
 Treatment of Diffuse in-stent Restenosis Combined with Cutting Balloon Angioplasty and intracoronary holmium Brachytherapy 
Authors
 강웅철  ;  변영섭  ;  조승연  ;  심원흠  ;  이종두  ;  장양수  ;  윤영원  ;  구본권  ;  박성하  ;  고영국  ;  최동훈 
Citation
 KOREAN CIRCULATION JOURNAL, Vol.33(8) : 671-679, 2003 
Journal Title
KOREAN CIRCULATION JOURNAL(순환기)
ISSN
 1738-5520 
Issue Date
2003
MeSH
In-stent restenosis;Cutting balloon angioplasty;Intracoronary 166Ho brachytherapy
Keywords
In-stent restenosis;Cutting balloon angioplasty;Intracoronary 166Ho brachytherapy
Abstract
Background and Objectives : A cutting balloon angioplasty for the treatment of diffuse in-stent restenosis has been reported to be superior to conventional percutaneous transluminal coronary angioplasty. Intracoronary radiation therapy is also a novel technique for preventing a recurrence of in-stent restenosis following percutaneous coronary intervention. Holmium (166Ho) is a high-energy β-emitter, which is available in liquid form. We performed a cutting balloon angioplasty, with subsequent intracoronary 166Ho brachytherapy, for the treatment of in-stent restenosis.
Subjects and Methods : Fifty two patients, with in-stent restenosis, were treated with cutting balloon angioplasty and intracoronary 166Ho brachytherapy. For the irradiation, a balloon approximately 10 mm longer than the stent was used. Radiation doses of 18 Gy at a depth of 1 mm from balloon-artery interface were used. A quantitative coronary angiography was performed during the procedure and at the 6-month follow-up. The patients were followed clinically for an average of 16.8±9.8 months. Results : The procedures were successful in all patients. The minimal luminal diameter of in-stent restenosis lesions, initially and after treatment, and the lesion length were 0.58±0.30 and 2.55±0.29 mm, and 20.7±7.1 mm, respectively. Thirty four (65.4%) patients completed the angiographic follow-up at 6 months. The minimal luminal diameter of lesion and late loss were 2.03±0.83 and 0.57±0.79 mm, respectively. The target lesion restenosis rate was 14.7%. No patients presented with MACE, such as MI, death or stent thrombosis. Conclusion : The combination of cutting balloon angioplasty and intracoronary 166Ho brachytherapy was feasible, safe and effective for the treatment of diffuse in-stent restenosis.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114181
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