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Expression of Estrogen Receptor-β in Normal Mammary and Tumor Tissues: is it Protective in Breast Carcinogenesis?

Authors
 Byeong-Woo Park  ;  Ki-Suk Kim  ;  Gwi Eon Kim  ;  Joo-Hang Kim  ;  Woo-Ick Yang  ;  Soon Won Hong  ;  Kyong Sik Lee  ;  Seung-Sang Ko  ;  Min-Kyu Heo 
Citation
 BREAST CANCER RESEARCH AND TREATMENT, Vol.80(1) : 79-85, 2003 
Journal Title
 BREAST CANCER RESEARCH AND TREATMENT 
ISSN
 0167-6806 
Issue Date
2003
MeSH
Biomarkers, Tumor/metabolism* ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism* ; Breast Neoplasms/pathology* ; Disease-Free Survival ; Estrogen Receptor beta ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; In Situ Hybridization ; Lymphatic Metastasis ; Prognosis ; RNA, Messenger/metabolism ; RNA, Neoplasm/metabolism ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism*
Keywords
12889601
Abstract
Using messenger RNA (mRNA) in situ hybridization, we investigated estrogen receptor-β (ERβ) mRNA levels in normal mammary, benign breast tumor (BBT), breast cancer (BC), and metastatic lymph node tissues to verify the role of ERβ in BC development and progression. ERβ expression was significantly decreased in BC and metastatic lymph node tissues compared with normal mammary and BBT tissues (p < 0.01). The intensity and extent of ERβ mRNA signals were also significantly lower in BC and metastatic lymph node tissues than in the normal mammary and BBT tissues (p < 0.01). An inverse relationship was found between ERβ mRNA level and both histologic grade (p = 0.091) and progesterone receptor expression (p = 0.052) with marginal significance, but no significant association was noted between ERβ expression in cancer tissues and the other clinico-pathologic data. The 3-year distant relapse-free survival probability was found to be independent of ERβ expression. Collectively, ERβ mRNA decreases in the process of BC development, but seems to be associated with poor differentiation.
Full Text
http://link.springer.com/article/10.1023/A:1024406223619
DOI
10.1023/A:1024406223619
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gwi Eon(김귀언)
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114133
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