Cited 61 times in
Expression of Estrogen Receptor-β in Normal Mammary and Tumor Tissues: is it Protective in Breast Carcinogenesis?
DC Field | Value | Language |
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dc.contributor.author | 김귀언 | - |
dc.contributor.author | 박병우 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 홍순원 | - |
dc.date.accessioned | 2015-07-15T17:03:16Z | - |
dc.date.available | 2015-07-15T17:03:16Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114133 | - |
dc.description.abstract | Using messenger RNA (mRNA) in situ hybridization, we investigated estrogen receptor-β (ERβ) mRNA levels in normal mammary, benign breast tumor (BBT), breast cancer (BC), and metastatic lymph node tissues to verify the role of ERβ in BC development and progression. ERβ expression was significantly decreased in BC and metastatic lymph node tissues compared with normal mammary and BBT tissues (p < 0.01). The intensity and extent of ERβ mRNA signals were also significantly lower in BC and metastatic lymph node tissues than in the normal mammary and BBT tissues (p < 0.01). An inverse relationship was found between ERβ mRNA level and both histologic grade (p = 0.091) and progesterone receptor expression (p = 0.052) with marginal significance, but no significant association was noted between ERβ expression in cancer tissues and the other clinico-pathologic data. The 3-year distant relapse-free survival probability was found to be independent of ERβ expression. Collectively, ERβ mRNA decreases in the process of BC development, but seems to be associated with poor differentiation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 79~85 | - |
dc.relation.isPartOf | BREAST CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/genetics | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/pathology* | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Estrogen Receptor beta | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | RNA, Neoplasm/metabolism | - |
dc.subject.MESH | Receptors, Estrogen/genetics | - |
dc.subject.MESH | Receptors, Estrogen/metabolism* | - |
dc.title | Expression of Estrogen Receptor-β in Normal Mammary and Tumor Tissues: is it Protective in Breast Carcinogenesis? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Byeong-Woo Park | - |
dc.contributor.googleauthor | Ki-Suk Kim | - |
dc.contributor.googleauthor | Gwi Eon Kim | - |
dc.contributor.googleauthor | Joo-Hang Kim | - |
dc.contributor.googleauthor | Woo-Ick Yang | - |
dc.contributor.googleauthor | Soon Won Hong | - |
dc.contributor.googleauthor | Kyong Sik Lee | - |
dc.contributor.googleauthor | Seung-Sang Ko | - |
dc.contributor.googleauthor | Min-Kyu Heo | - |
dc.identifier.doi | 10.1023/A:1024406223619 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00321 | - |
dc.contributor.localId | A01475 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A04411 | - |
dc.relation.journalcode | J00403 | - |
dc.identifier.eissn | 1573-7217 | - |
dc.identifier.pmid | 12889601 | - |
dc.identifier.url | http://link.springer.com/article/10.1023/A:1024406223619 | - |
dc.subject.keyword | 12889601 | - |
dc.contributor.alternativeName | Kim, Gwi Eon | - |
dc.contributor.alternativeName | Park, Byeong Woo | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Kim, Gwi Eon | - |
dc.contributor.affiliatedAuthor | Park, Byeong Woo | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Hong, Soon Won | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 80 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 79 | - |
dc.citation.endPage | 85 | - |
dc.identifier.bibliographicCitation | BREAST CANCER RESEARCH AND TREATMENT, Vol.80(1) : 79-85, 2003 | - |
dc.identifier.rimsid | 52013 | - |
dc.type.rims | ART | - |
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