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Expression of transforming growth factor-β1 and transforming growth factor-β receptors in hepatocellular carcinoma and dysplastic nodules

Authors
 So Ya Paik  ;  Young Nyun Park  ;  Chanil Park  ;  Hoguen Kim 
Citation
 MODERN PATHOLOGY, Vol.16(1) : 86-96, 2003 
Journal Title
 MODERN PATHOLOGY 
ISSN
 0893-3952 
Issue Date
2003
MeSH
Carcinoma, Hepatocellular/metabolism* ; Carcinoma, Hepatocellular/pathology ; Focal Nodular Hyperplasia/metabolism* ; Focal Nodular Hyperplasia/pathology ; Humans ; Immunoenzyme Techniques ; Ki-67 Antigen/metabolism ; Liver Neoplasms/metabolism* ; Liver Neoplasms/pathology ; Precancerous Conditions/metabolism* ; Precancerous Conditions/pathology ; Receptors, Transforming Growth Factor beta/metabolism* ; Transforming Growth Factor beta/metabolism* ; Transforming Growth Factor beta1
Keywords
Hepatocellular carcinoma ; TGF- 1 ; TGF- receptor I ; TGF- receptor II
Abstract
In this study we analyzed by immunohistochemistry the expression of TGF-beta1 protein and TGF-beta receptors I and II in 4 low-grade dysplastic nodules, 2 high-grade dysplastic nodules, 6 early, 22 small, and 62 advanced hepatocellular carcinomas. The expression of TGF-beta1 protein by hepatocytes was decreased in advanced hepatocellular carcinoma compared with small or early hepatocellular carcinoma(P < .05). Frequent and intense staining of TGF-beta1 protein was noted in the sinusoidal endothelium of advanced hepatocellular carcinomas despite of its decreased staining in hepatocellular carcinoma cells. Reduced expression of TGF-beta receptors I and II compared with surrounding nontumorous tissue were noted from the early hepatocellular carcinoma stage suggesting that down-regulation of TGF-beta receptors is correlated with progression from premalignant to malignant phenotype. Reduced expression of both TGF-beta1 and TGF-beta receptor II in neoplastic hepatocytes were also significantly correlated with increased tumor size and increased proliferative activity(P < .05). These findings suggest that during hepatocarcinogenesis, the inhibitory effects of TGF-beta1 protein on hepatocellular carcinoma cells is outweighed by its effects on stromal elements, which, overall, contributes indirectly to a tumor growth stimulatory environment. Also, the growth-inhibitory effects of TGF-beta1 may have been further negated by reduced TGF-beta receptors on hepatocellular carcinoma cells.
Files in This Item:
T200305494.pdf Download
DOI
10.1097/01.MP.0000047308.03300.9C
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ho Keun(김호근)
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Chan Il(박찬일)
Paik, So Ya(백소야)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114126
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