Cited 28 times in
Expression of transforming growth factor-β1 and transforming growth factor-β receptors in hepatocellular carcinoma and dysplastic nodules
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김호근 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 박찬일 | - |
dc.contributor.author | 백소야 | - |
dc.date.accessioned | 2015-07-15T17:03:04Z | - |
dc.date.available | 2015-07-15T17:03:04Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0893-3952 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114126 | - |
dc.description.abstract | In this study we analyzed by immunohistochemistry the expression of TGF-beta1 protein and TGF-beta receptors I and II in 4 low-grade dysplastic nodules, 2 high-grade dysplastic nodules, 6 early, 22 small, and 62 advanced hepatocellular carcinomas. The expression of TGF-beta1 protein by hepatocytes was decreased in advanced hepatocellular carcinoma compared with small or early hepatocellular carcinoma(P < .05). Frequent and intense staining of TGF-beta1 protein was noted in the sinusoidal endothelium of advanced hepatocellular carcinomas despite of its decreased staining in hepatocellular carcinoma cells. Reduced expression of TGF-beta receptors I and II compared with surrounding nontumorous tissue were noted from the early hepatocellular carcinoma stage suggesting that down-regulation of TGF-beta receptors is correlated with progression from premalignant to malignant phenotype. Reduced expression of both TGF-beta1 and TGF-beta receptor II in neoplastic hepatocytes were also significantly correlated with increased tumor size and increased proliferative activity(P < .05). These findings suggest that during hepatocarcinogenesis, the inhibitory effects of TGF-beta1 protein on hepatocellular carcinoma cells is outweighed by its effects on stromal elements, which, overall, contributes indirectly to a tumor growth stimulatory environment. Also, the growth-inhibitory effects of TGF-beta1 may have been further negated by reduced TGF-beta receptors on hepatocellular carcinoma cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 86~96 | - |
dc.relation.isPartOf | MODERN PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Carcinoma, Hepatocellular/metabolism* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology | - |
dc.subject.MESH | Focal Nodular Hyperplasia/metabolism* | - |
dc.subject.MESH | Focal Nodular Hyperplasia/pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoenzyme Techniques | - |
dc.subject.MESH | Ki-67 Antigen/metabolism | - |
dc.subject.MESH | Liver Neoplasms/metabolism* | - |
dc.subject.MESH | Liver Neoplasms/pathology | - |
dc.subject.MESH | Precancerous Conditions/metabolism* | - |
dc.subject.MESH | Precancerous Conditions/pathology | - |
dc.subject.MESH | Receptors, Transforming Growth Factor beta/metabolism* | - |
dc.subject.MESH | Transforming Growth Factor beta/metabolism* | - |
dc.subject.MESH | Transforming Growth Factor beta1 | - |
dc.title | Expression of transforming growth factor-β1 and transforming growth factor-β receptors in hepatocellular carcinoma and dysplastic nodules | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | So Ya Paik | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Chanil Park | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.identifier.doi | 10.1097/01.MP.0000047308.03300.9C | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01710 | - |
dc.contributor.localId | A01821 | - |
dc.relation.journalcode | J02238 | - |
dc.identifier.eissn | 1530-0285 | - |
dc.identifier.pmid | 12527718 | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | TGF- 1 | - |
dc.subject.keyword | TGF- receptor I | - |
dc.subject.keyword | TGF- receptor II | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Park, Chan Il | - |
dc.contributor.alternativeName | Paik, So Ya | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Park, Chan Il | - |
dc.contributor.affiliatedAuthor | Paik, So Ya | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 86 | - |
dc.citation.endPage | 96 | - |
dc.identifier.bibliographicCitation | MODERN PATHOLOGY, Vol.16(1) : 86-96, 2003 | - |
dc.identifier.rimsid | 55732 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.