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Kaposi 육종의 임상 및 병리조직학적 연구

Other Titles
 Kaposi's sarcoma: A clinico-pathological study of 21 patients 
 천은영  ;  김세훈  ;  이민걸  ;  양우익 
 Korean Journal of Dermatology (대한피부과학회지), Vol.41(12) : 1603-1611, 2003 
Journal Title
Korean Journal of Dermatology(대한피부과학회지)
Issue Date
Kaposi's sarcoma ; HHV8 ; AIDS
Kaposi's sarcoma ; HHV8 ; AIDS
Background: Kaposi`s sarcoma (KS) is a mesenchymal tumor involving blood and lymphatic vessels. Viral oncogenesis by human herpesvirus 8 (HHV8) and cytokine-induced growth together with some state of immunocompromise represent important conditions for this tumor to develop. Objective: The purpose of this study was to document the clinical and histopathological features of KS in Korea. Methods: The medical records and histopathologic slides of patients with KS diagnosed at Yonsei University Medical Center from January, 1992 to March, 2003 were reviewed. We used immuno-histochemical stains for HHV8 to determine whether HHV8 is present in KS. Results: 1. Among the 21 patients, classic KS was found in 7, acquired immunodeficiency syndrome (AIDS)-associated KS in 3, and introgenic, immunosuppressive KS in 11. 2. Classic and introgenic KS most often have a preference for the lower extremities, while the upper body in AIDS-KS. Mucosal involvement and systemic organ involvement could be detected in AIDS-KS. 3. Immunohistochemical stains for HHV8 were positive in 100% with classic KS and AIDS KS, and 90.9% with immunosuppressive KS. 4. Classic KS responded well to local therapy and showed indolent course. Iatrogenic, immunosuppressive KS generally regressed after reduction or cessation of immunosuppressive drug therapy, but some of them showed resistance to therapy. For AIDS-KS, no systemic treatments have been shown to prolong survival. Conclusion: Because classic KS and iatrogenic, immunsoupressive KS generally have a benign coures, cautions are taken not to overtreat them. However, some cases of organ transplantation associated KS have an aggressive coures, prompting us to consider active treatments to save transplanted organ.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
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