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Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessive–compulsive disorder

Authors
 D.-H. Kang  ;  J. S. Kwon  ;  M. C. Lee  ;  D. S. Lee  ;  M. S. Kim  ;  H.-J. Park  ;  T. Youn  ;  J.-J. Kim 
Citation
 ACTA PSYCHIATRICA SCANDINAVICA, Vol.107(4) : 291-297, 2003 
Journal Title
 ACTA PSYCHIATRICA SCANDINAVICA 
ISSN
 0001-690X 
Issue Date
2003
MeSH
Adult ; Brain/metabolism* ; Cerebellum/physiology ; Cognition* ; Female ; Fluorodeoxyglucose F18 ; Frontal Lobe/physiology ; Glucose/metabolism* ; Humans ; Male ; Mental Recall ; Neuropsychological Tests ; Obsessive-Compulsive Disorder/physiopathology* ; Obsessive-Compulsive Disorder/therapy* ; Parietal Lobe/physiology ; Radiopharmaceuticals ; Tomography, Emission-Computed ; Treatment Outcome
Keywords
Obsessive compulsive disorder ; neuropsychology ; positron emission tomography
Abstract
OBJECTIVE: The study was designed to elucidate regional brain metabolic changes according to a treatment and their relationship with neuropsychological performance changes in obsessive-compulsive disorder (OCD). METHOD: Cerebral glucose metabolic rates were repeatedly measured before and after treatment in 10 patients with OCD using [18F]-2-fluoro-deoxyglucose positron emission tomography (PET). They were compared on a voxel-basis, and the correlations were counted between the regional metabolic changes and the degree to improvement on the neuropsychological assessments. RESULTS: After treatment, the patients showed significant (P < 0.005, two-tailed) regional metabolic changes in multiple brain areas involving frontal-subcortical circuits and parietal-cerebellar networks. Especially, the metabolic changes of the putamen, the cerebellum, and the hippocampus were significantly correlated with the improvement of the immediate- and delayed-recall scores of the Rey-Osterrieth Complex Figure Test (RCFT). CONCLUSION: These results suggest a possibility that metabolic changes of frontal-subcortical and parietal-cerebellar circuit changes may underlie cognitive improvements in patients with OCD.
Full Text
http://onlinelibrary.wiley.com/doi/10.1034/j.1600-0447.2003.00070.x/abstract
DOI
10.1034/j.1600-0447.2003.00070.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/114007
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