Cited 106 times in
Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessive–compulsive disorder
DC Field | Value | Language |
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dc.contributor.author | 박해정 | - |
dc.contributor.author | 김재진 | - |
dc.date.accessioned | 2015-07-15T16:59:30Z | - |
dc.date.available | 2015-07-15T16:59:30Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0001-690X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114007 | - |
dc.description.abstract | OBJECTIVE: The study was designed to elucidate regional brain metabolic changes according to a treatment and their relationship with neuropsychological performance changes in obsessive-compulsive disorder (OCD). METHOD: Cerebral glucose metabolic rates were repeatedly measured before and after treatment in 10 patients with OCD using [18F]-2-fluoro-deoxyglucose positron emission tomography (PET). They were compared on a voxel-basis, and the correlations were counted between the regional metabolic changes and the degree to improvement on the neuropsychological assessments. RESULTS: After treatment, the patients showed significant (P < 0.005, two-tailed) regional metabolic changes in multiple brain areas involving frontal-subcortical circuits and parietal-cerebellar networks. Especially, the metabolic changes of the putamen, the cerebellum, and the hippocampus were significantly correlated with the improvement of the immediate- and delayed-recall scores of the Rey-Osterrieth Complex Figure Test (RCFT). CONCLUSION: These results suggest a possibility that metabolic changes of frontal-subcortical and parietal-cerebellar circuit changes may underlie cognitive improvements in patients with OCD. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ACTA PSYCHIATRICA SCANDINAVICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Brain/metabolism* | - |
dc.subject.MESH | Cerebellum/physiology | - |
dc.subject.MESH | Cognition* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorodeoxyglucose F18 | - |
dc.subject.MESH | Frontal Lobe/physiology | - |
dc.subject.MESH | Glucose/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mental Recall | - |
dc.subject.MESH | Neuropsychological Tests | - |
dc.subject.MESH | Obsessive-Compulsive Disorder/physiopathology* | - |
dc.subject.MESH | Obsessive-Compulsive Disorder/therapy* | - |
dc.subject.MESH | Parietal Lobe/physiology | - |
dc.subject.MESH | Radiopharmaceuticals | - |
dc.subject.MESH | Tomography, Emission-Computed | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessive–compulsive disorder | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Nuclear Medicine (핵의학) | - |
dc.contributor.googleauthor | D.-H. Kang | - |
dc.contributor.googleauthor | J. S. Kwon | - |
dc.contributor.googleauthor | J.-J. Kim | - |
dc.contributor.googleauthor | T. Youn | - |
dc.contributor.googleauthor | H.-J. Park | - |
dc.contributor.googleauthor | M. S. Kim | - |
dc.contributor.googleauthor | D. S. Lee | - |
dc.contributor.googleauthor | M. C. Lee | - |
dc.identifier.doi | 10.1034/j.1600-0447.2003.00070.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01730 | - |
dc.relation.journalcode | J00032 | - |
dc.identifier.eissn | 1600-0447 | - |
dc.identifier.pmid | 12662252 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1034/j.1600-0447.2003.00070.x/abstract | - |
dc.subject.keyword | Obsessive compulsive disorder | - |
dc.subject.keyword | neuropsychology | - |
dc.subject.keyword | positron emission tomography | - |
dc.contributor.alternativeName | Park, Hae Jeong | - |
dc.contributor.affiliatedAuthor | Park, Hae Jeong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 107 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 291 | - |
dc.citation.endPage | 297 | - |
dc.identifier.bibliographicCitation | ACTA PSYCHIATRICA SCANDINAVICA, Vol.107(4) : 291-297, 2003 | - |
dc.identifier.rimsid | 55643 | - |
dc.type.rims | ART | - |
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