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Intercellular adhesion molecule-1 polymorphisms in Korean patients with Behcet's disease

Authors
 Eun Hee Kim  ;  Jee Won Mok  ;  KyungSook Park  ;  SungNack Lee  ;  Eun-So Lee  ;  Dongsik Bang 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.18(3) : 415-418, 2003 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2003
MeSH
Adult ; Behcet Syndrome/ethnology ; Behcet Syndrome/genetics* ; Female ; Gene Frequency ; Genetic Predisposition to Disease/epidemiology ; Humans ; Intercellular Adhesion Molecule-1/genetics* ; Korea/epidemiology ; Male ; Middle Aged ; Phenotype ; Polymorphism, Restriction Fragment Length* ; Risk Factors
Keywords
Intercellular Adhesion Molecule-1 ; Behcet Symdrome ; Polymorphism ; Restriction Fragment Length
Abstract
Intercellular adhesion molecule-1 (ICAM-1) is expressed on vascular endothelial cells and its expression increases during the inflammatory response in patients with active Behcet's disease (BD). The ICAM1 gene mutations are associated with BD in Caucasians, but clinical features of the mutation phenotype are unknown. We analyzed ICAM1 polymorphisms in Korean BD patients to determine if there was an association between particular mutations and clinical symptoms. The prevalence of ICAM1R241G and ICAM1K469E polymorphisms was determined among 197 patients with BD and 248 healthy controls using BsrG1 and BstU1 PCR-RFLP. The frequency of both genotypes ICAM1469 * K/ * E and ICAM-1469 * E/ * E was significantly higher in BD patients compared with controls (66.0% vs 52.4%, p=0.004, OR=1.28, 95% CI 1.08-1.50) and the allele frequency of ICAM1469 * E was higher in patients with skin lesions (0.41), genital ulcers (0.41), vasculitis (0.43), ocular lesions (0.41) and arthritis (0.39) than in controls (0.31). Only one heterozygote, ICAM1241G/R, was detected in BD patients but the ICAM1241 * R mutation was not found in any of the 248 healthy controls. These results show that the ICAM1 mutation is associated with BD susceptibility, and is another genetic risk factor for BD among the Korean population.
Files in This Item:
T200304920.pdf Download
DOI
10.3346/jkms.2003.18.3.415
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Bang, Dong Sik(방동식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113962
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