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Intercellular adhesion molecule-1 polymorphisms in Korean patients with Behcet's disease

DC FieldValueLanguage
dc.contributor.author방동식-
dc.date.accessioned2015-07-15T16:58:11Z-
dc.date.available2015-07-15T16:58:11Z-
dc.date.issued2003-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/113962-
dc.description.abstractIntercellular adhesion molecule-1 (ICAM-1) is expressed on vascular endothelial cells and its expression increases during the inflammatory response in patients with active Behcet's disease (BD). The ICAM1 gene mutations are associated with BD in Caucasians, but clinical features of the mutation phenotype are unknown. We analyzed ICAM1 polymorphisms in Korean BD patients to determine if there was an association between particular mutations and clinical symptoms. The prevalence of ICAM1R241G and ICAM1K469E polymorphisms was determined among 197 patients with BD and 248 healthy controls using BsrG1 and BstU1 PCR-RFLP. The frequency of both genotypes ICAM1469 * K/ * E and ICAM-1469 * E/ * E was significantly higher in BD patients compared with controls (66.0% vs 52.4%, p=0.004, OR=1.28, 95% CI 1.08-1.50) and the allele frequency of ICAM1469 * E was higher in patients with skin lesions (0.41), genital ulcers (0.41), vasculitis (0.43), ocular lesions (0.41) and arthritis (0.39) than in controls (0.31). Only one heterozygote, ICAM1241G/R, was detected in BD patients but the ICAM1241 * R mutation was not found in any of the 248 healthy controls. These results show that the ICAM1 mutation is associated with BD susceptibility, and is another genetic risk factor for BD among the Korean population.-
dc.description.statementOfResponsibilityopen-
dc.format.extent415~418-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBehcet Syndrome/ethnology-
dc.subject.MESHBehcet Syndrome/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHGene Frequency-
dc.subject.MESHGenetic Predisposition to Disease/epidemiology-
dc.subject.MESHHumans-
dc.subject.MESHIntercellular Adhesion Molecule-1/genetics*-
dc.subject.MESHKorea/epidemiology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPhenotype-
dc.subject.MESHPolymorphism, Restriction Fragment Length*-
dc.subject.MESHRisk Factors-
dc.titleIntercellular adhesion molecule-1 polymorphisms in Korean patients with Behcet's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorEun Hee Kim-
dc.contributor.googleauthorJee Won Mok-
dc.contributor.googleauthorKyungSook Park-
dc.contributor.googleauthorSungNack Lee-
dc.contributor.googleauthorEun-So Lee-
dc.contributor.googleauthorDongsik Bang-
dc.identifier.doi10.3346/jkms.2003.18.3.415-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01784-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid12808331-
dc.subject.keywordIntercellular Adhesion Molecule-1-
dc.subject.keywordBehcet Symdrome-
dc.subject.keywordPolymorphism-
dc.subject.keywordRestriction Fragment Length-
dc.contributor.alternativeNameBang, Dong Sik-
dc.contributor.affiliatedAuthorBang, Dong Sik-
dc.rights.accessRightsfree-
dc.citation.volume18-
dc.citation.number3-
dc.citation.startPage415-
dc.citation.endPage418-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.18(3) : 415-418, 2003-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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