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Circulating interleukin 17 is increased in the acute stage of Kawasaki disease

Authors
 MH Sohn  ;  SY Noh  ;  DS Kim  ;  KM Shin  ;  W Chang 
Citation
 SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, Vol.32(6) : 364-366, 2003 
Journal Title
 SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 
ISSN
 0300-9742 
Issue Date
2003
MeSH
Acute Disease ; C-Reactive Protein/metabolism ; Case-Control Studies ; Child ; Child, Preschool ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Infant ; Inflammation Mediators/analysis* ; Inflammation Mediators/blood ; Interleukin-17/analysis ; Interleukin-17/blood* ; Interleukin-6/blood* ; Male ; Mucocutaneous Lymph Node Syndrome/blood* ; Mucocutaneous Lymph Node Syndrome/diagnosis* ; Probability ; Prognosis ; Reference Values ; Sampling Studies ; Sensitivity and Specificity ; Severity of Illness Index
Keywords
Kawasaki disease ; interleukin‐17 ; interleukin‐6
Abstract
OBJECTIVES: During the acute phase, patients with Kawasaki disease (KD), an acute systemic vasculitis, demonstrate a drastic increase in serum interleukin-6 (IL-6), which parallels the duration of the fever. Recently, IL-17 has been reported to induce IL-6 production. The aim of this study was to elucidate the involvement of IL-17 in the pathogenesis of KD. METHODS: Serum samples were obtained from patients with KD (n=30) and normal controls (n=20), and the concentrations of IL-17 and IL-6 measured using enzyme-linked immunosorbent assay (ELISA). RESULTS: Compared with the normal controls (2.08 +/- 2.14 pg/mL), serum IL-17 was markedly elevated in patients with acute KD (25.47 +/- 5.05 pg/mL): levels gradually decreased in the subacute phase (5.94 +/- 2.83 pg/mL). In the acute phase, levels of IL-6 were 83.52 +/- 19.12 pg/L, which correlated well with the serum levels of IL-17. CONCLUSION: These results suggest that IL-17 may be involved in the development of, or the effects of inflammation in KD.
Full Text
http://informahealthcare.com/doi/abs/10.1080/03009740410005034
DOI
10.1080/03009740410005034
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/113956
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