Cited 35 times in
Circulating interleukin 17 is increased in the acute stage of Kawasaki disease
DC Field | Value | Language |
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dc.contributor.author | 김동수 | - |
dc.contributor.author | 손명현 | - |
dc.date.accessioned | 2015-07-15T16:58:00Z | - |
dc.date.available | 2015-07-15T16:58:00Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0300-9742 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113956 | - |
dc.description.abstract | OBJECTIVES: During the acute phase, patients with Kawasaki disease (KD), an acute systemic vasculitis, demonstrate a drastic increase in serum interleukin-6 (IL-6), which parallels the duration of the fever. Recently, IL-17 has been reported to induce IL-6 production. The aim of this study was to elucidate the involvement of IL-17 in the pathogenesis of KD. METHODS: Serum samples were obtained from patients with KD (n=30) and normal controls (n=20), and the concentrations of IL-17 and IL-6 measured using enzyme-linked immunosorbent assay (ELISA). RESULTS: Compared with the normal controls (2.08 +/- 2.14 pg/mL), serum IL-17 was markedly elevated in patients with acute KD (25.47 +/- 5.05 pg/mL): levels gradually decreased in the subacute phase (5.94 +/- 2.83 pg/mL). In the acute phase, levels of IL-6 were 83.52 +/- 19.12 pg/L, which correlated well with the serum levels of IL-17. CONCLUSION: These results suggest that IL-17 may be involved in the development of, or the effects of inflammation in KD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 364~366 | - |
dc.relation.isPartOf | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | C-Reactive Protein/metabolism | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Inflammation Mediators/analysis* | - |
dc.subject.MESH | Inflammation Mediators/blood | - |
dc.subject.MESH | Interleukin-17/analysis | - |
dc.subject.MESH | Interleukin-17/blood* | - |
dc.subject.MESH | Interleukin-6/blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mucocutaneous Lymph Node Syndrome/blood* | - |
dc.subject.MESH | Mucocutaneous Lymph Node Syndrome/diagnosis* | - |
dc.subject.MESH | Probability | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Reference Values | - |
dc.subject.MESH | Sampling Studies | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.title | Circulating interleukin 17 is increased in the acute stage of Kawasaki disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | MH Sohn | - |
dc.contributor.googleauthor | SY Noh | - |
dc.contributor.googleauthor | DS Kim | - |
dc.contributor.googleauthor | KM Shin | - |
dc.contributor.googleauthor | W Chang | - |
dc.identifier.doi | 10.1080/03009740410005034 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01967 | - |
dc.contributor.localId | A00405 | - |
dc.relation.journalcode | J02635 | - |
dc.identifier.eissn | 1502-7732 | - |
dc.identifier.pmid | 10.1080/03009740410005034 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.1080/03009740410005034 | - |
dc.subject.keyword | Kawasaki disease | - |
dc.subject.keyword | interleukin‐17 | - |
dc.subject.keyword | interleukin‐6 | - |
dc.contributor.alternativeName | Kim, Dong Soo | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Dong Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 32 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 364 | - |
dc.citation.endPage | 366 | - |
dc.identifier.bibliographicCitation | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, Vol.32(6) : 364-366, 2003 | - |
dc.identifier.rimsid | 54015 | - |
dc.type.rims | ART | - |
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